Results 91 to 100 of about 25,148 (262)

Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom

British Journal of Haematology, EarlyView.
Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas, Gabriel Naylor‐Layland, Clare Brown, Ahmad Alabdulkarim, Jennifer Ryan, Frances Wadelin, Samah Alimam, Phyo Wint Wint Tun, Jonathan Lambert, Jennifer O'Sullivan, Andrew J. Wilson, Laith Tafesh, Andrew McGregor, Simone Claudiani, Andrew Innes, Emily Booth, James Leveson, Steve Knapper, Mamta Garg, Mani Dubey, Theodora Vatopoulou, Charlotte Brierley, Wai Ka Natalie Leung, Graham Greenfield, Mary Frances McMullin, Alesia Khan, Kate Milne, Duncan Brian, Anna Godfrey, Claire N. Harrison, Bethan Psaila, Patrick Harrington, Amy Kirkwood, Tim C. P. Somervaille, Donal P. McLornan, on behalf of the UK Blood Cancer Research Network MPN Clinical Study Group   +35 more
wiley   +1 more source

Patterns of bacteraemia aetiology [PDF]

The Lancet Infectious Diseases, 2017
Alan, Cross, Myron M, Levine
openaire   +2 more sources

First‐In‐Human Study: Dose Expansion of E7130 in Urothelial Carcinoma and Squamous Cell Carcinoma of the Head and Neck

Cancer Science, EarlyView.
The dose escalation part of the first‐in‐human study of E7130 in patients with advanced solid tumors determined the Recommended Phase 2 Dose of E7130 (480 μg/m2 Q3W). The dose expansion part (presented here) examined safety/preliminary efficacy in patients with squamous cell carcinoma of the head and neck and urothelial carcinoma.
Nobuaki Matsubara, Ken Saijo, Yasushi Shimizu, Susumu Okano, Kenji Nakano, Naoki Nishio, Tomoyuki Otsuka, Hirofumi Kuno, Takuma Miura, Tomoki Kubota, Hiroki Ikezawa, Yuko Umetsu, Ken Ito, Abraham Apfel, Yuanqing Ye, Yoshitaka Honma   +15 more
wiley   +1 more source

Clinical and genomic characterization of Serratia bloodstream infections

CMI Communications
Objectives: Previously considered a rare opportunistic pathogen, Serratia is now an emerging cause of bacteraemia. We compared the risk factors and outcomes of patients with Serratia bacteraemia relative to other Enterobacterales in a cohort of ...
Roberta Monardo, Lawrence P. Park, Felicia Ruffin, Phillip Cox, An Q. Dinh, Rachel E. Korn, Parisa Farahani, Marco Ripa, Antonella Castagna, Blake M. Hanson, Vance G. Fowler, Jr., Joshua T. Thaden, Stacey A. Maskarinec   +12 more
doaj   +1 more source

Early predictors of cognitive trajectories from birth to adolescence in children born extremely preterm

Developmental Medicine &Child Neurology, EarlyView.
At 2 years, 10 years, and 15 years, the presence of early white matter injury (WMI) moderated associations between lower social risk and cognitive functioning in the social disadvantage index group x WMI interactions for combined abilities. Findings suggest that the benefits of low social risk were present in those without early WMI, but are ...
Stephen R. Hooper, Robert M. Joseph, T. Michael O′Shea, Karl C. K. Kuban, Rachana Singh, Jean A. Frazier, Genevieve Taylor, Xianming Tan, Rebecca C. Fry, Hudson P. Santos Jr, on behalf of the ELGAN Study Investigators   +10 more
wiley   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury

BMJ Paediatrics Open
Introduction Neonatal sepsis remains a leading cause of morbidity and mortality across all healthcare systems. Acute kidney injury (AKI) is common in neonates and is associated with poor clinical outcomes.
Richard Drew, Atif Awan, Michael A Boyle, Dermot Michael Wildes, Daniel O’Reilly, Elysha Brennan   +5 more
doaj   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

Prevalence and pattern of bacteraemia among HIV-infected under -five children in a tertiary hospital in Kano, NigeriaAbstract: Background: Bacteraemia is an invasive bacterial disease of childhood that is associated with serious complications and high mo

Nigerian Journal of Paediatrics
Background: Bacteraemia is an invasive bacterial disease of childhood that is associated with serious complications and high mortality especially in immunocomprised HIV infected children.
Adisa AK, Hassan-Hanga F , Oyelami OA
doaj  

Clinical outcome of combination of vancomycin and ceftaroline versus vancomycin monotherapy for treatment of methicillin resistant Staphylococcus aureus bloodstream infection

BMC Infectious Diseases
Background The role of combination therapies for serious methicillin-resistant Staphylococcus aureus (MRSA) infections is widely debated. Methods This retrospective cohort study included adults with MRSA bacteraemia treated between January 1, 2013, to ...
Rami Waked, Leslie Coats, Adriana Rosato, Christina F. Yen, Emily Wood, Daniel J. Diekema, Kristina E. Rokas, Nicholas J. Mercuro   +7 more
doaj   +1 more source