Results 91 to 100 of about 2,032,795 (373)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biocontamination in the dairy industry: The effect of raw milk conditioning film on the adhesion of Escherichia coli

Czech Journal of Food Sciences
Conditioning films on surfaces employed in the dairy industry serve as the precursors to the formation of pathogenic biofilms that impact product quality and consumer safety. Conditioning films have been studied from several aspects.
Zakariyae El hafa, Ikhlas Hani Chennoufi, Hafida Zahir, Mostafa El louali, Hassan Latrache   +4 more
doaj   +1 more source

Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The Staphylococcus aureus surface protein clumping factor A (ClfA) binds to the blood plasma protein fibrinogen (Fg) via molecular interactions that are poorly understood.
Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, J. Geoghegan, Y. Dufrêne   +5 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

HELICOBACTER PYLORI OIPA VIRULENCE GENE AS A MOLECULAR MARKER OF SEVERE GASTROPATHIES [PDF]

Arquivos de Gastroenterologia
Background: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H.
Diogo Nery MACIEL, Lucas Luiz de Lima SILVA, Leandro do Prado ASSUNÇÃO, Lucas Trevizani RASMUSSEN, Mônica Santiago BARBOSA   +4 more
doaj   +1 more source

CuO Nanoparticles-Containing Highly Transparent and Superhydrophobic Coatings with Extremely Low Bacterial Adhesion and Excellent Bactericidal Property.

ACS Applied Materials and Interfaces, 2018
Human health and industrial instruments have been suffering from bacterial colonization on the surface of materials for a long time. Recently, antibacterial coatings are regarded as the new strategy to resist bacterial pathogens.
Tingting Ren, Mingqing Yang, Kaikai Wang, Yue Zhang, Junhui He   +4 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparison of Streptococcus mutans adhesion to polished and glazed surfaces of three CAD/CAM ceramics: an in vitro study

BMC Oral Health
Objectives Bacterial adhesion to dental restorations plays a critical role in the development of biofilms, contributing to periodontal disease and implant failure.
Mehran Nourbakhsh, Arash Zarbakhsh, Saman Kalantari, Nasim Kashef   +3 more
doaj   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Bacterial Adhesion on Femtosecond Laser-Modified Polyethylene

Materials, 2019
In this study, femtosecond laser-induced sub-micrometer structures are generated to modify polyethylene (PE) surface topographies. These surfaces were subjected to bacterial colonization studies with Escherichia coli and Staphylococcus aureus as test ...
Karin Schwibbert, Friederike Menzel, Nadja Epperlein, J. Bonse, J. Krüger   +4 more
semanticscholar   +1 more source