Results 51 to 60 of about 1,761,029 (289)

Synthesis and evaluation of troponoids as a new class of antibiotics [PDF]

, 2018
Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against Staphylococcus ...
Adegboyega, Patrick, Cao, Feng, Donlin, Maureen J., Elagawany, Mohamed, Elgendy, Bahaa, Meyers, Marvin J., Murelli, Ryan P., Orth, Cari, Tavis, John E.   +8 more
core   +4 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]

, 2018
Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Quartz crystal microbalance use in biological studies [PDF]

, 1972
Design, development, and applications of quartz crystal microbalance are discussed. Two types of crystals are used. One serves as reference and other senses changes in mass.
Godfrey, J. F., Green, R. H., Laue, E. G., Laue, T. M., Paik, W. W., Wardle, M. D.   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models

npj Vaccines
Staphylococcus aureus is a major cause of bacterial infection-related deaths. Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies.
Jan T. Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, Jeffrey Fernandez, Ashley L. DuMont, Anna O’Keeffe, Sergey R. Konstantinov, Brian Morrow, Peter Burghout, Jan Grijpstra, Miranda M. C. van Beers, Chakkumkal Anish, Michel Beurret, Jeroen Geurtsen, Pauline M. L. Rood, Oliver Koeberling, Miaomiao Shi, Germie P. J. M. van den Dobbelsteen   +18 more
doaj   +1 more source

A note on the conservation characteristics of baled grass silages ensiled with different additives. [PDF]

, 2010
peer-reviewedThe effects of contrasting conventional silage additives on chemical composition, aerobic stability and deterioration, and mould development in baled silage were investigated.
Forristal, P.D., Keles, G., O'Kiely, Padraig   +2 more
core  

Optimization of pathogenicity assays to study the Arabidopsis thaliana-Xanthomonas campestris pv. campastris pathosystem [PDF]

, 2005
The cruciferous weed Arabidopsis thaliana and the causal agent of black rot disease of Crucifers Xanthomonas campestris pv. campestris ( Xcc ) are both model organisms in plant pathology.
Alvarez, Bretschneider, Buell, da Silva, Godard, Hugouvieux, Katagiri, Lacomme, Lummerzheim, Lummerzheim, Quirino, Shaw, Simpson, Simpson, Slater, Somerville, Tang, Vicente, Vorholter, Williams, Winson   +20 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source