Results 61 to 70 of about 1,761,029 (289)

A randomized phase 1/2a trial of ExPEC10V vaccine in adults with a history of UTI

npj Vaccines
The safety, reactogenicity, and immunogenicity of 3 doses of ExPEC10V (VAC52416), a vaccine candidate to prevent invasive Escherichia coli disease, were assessed in a phase 1/2a study (NCT03819049). In Cohort 1, ExPEC10V was well tolerated; the high dose
Carlos A. Fierro, Michal Sarnecki, Bart Spiessens, Oscar Go, Tracey A. Day, Todd A. Davies, Germie van den Dobbelsteen, Jan Poolman, Darren Abbanat, Wouter Haazen   +9 more
doaj   +1 more source

Segregation of sister chromosomes during the shape change of developing Myxococcus xanthus cells

Journal of Bacteriology
Chromosome organization is critical for the maintenance of genetic integrity. Most studies of bacterial nucleoids have focused on growing rod-shaped organisms. Studying nucleoid dynamics during Myxococcus xanthus development offers the unique opportunity
Y. Hoang, Yann S. Dufour, Lee Kroos
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Isolation, identification, and monitoring of antibiotic resistance in Pasteurella multocida and Mannheimia haemolytica isolated from sheep in East Azerbaijan province, Iran [PDF]

Archives of Razi Institute, 2016
The present study was carried out in order to isolate, identify, and assess the antimicrobial susceptibility of the causative agent(s) of pneumonic pasteurellosis in sheep in East Azerbaijan province, northwest of Iran.
I. Khalili, R. Ghadimipour, R. Ghaderi, GH. Shokri, A.R. Jabbari, N. Razmaraii, M. Ebrahimi   +6 more
doaj   +1 more source

Bacterial invasion potential in water is determined by nutrient availability and the indigenous community [PDF]

, 2013
In drinking water (DW) and the distribution systems, bacterial growth and biofilm formation have to be controlled both for limiting taste or odour development and preventing clogging or biocorrosion problems. After a contamination with undesired bacteria,
Boon, Nico, De Roy, Karen, Van Nevel, Sam   +2 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

eLife
Bacterial contractile injection systems (CIS) are phage tail-like macromolecular complexes that mediate cell-cell interactions by injecting effector proteins into target cells.
Bastien Casu, Joseph W Sallmen, Peter E Haas, Govind Chandra, Pavel Afanasyev, Jingwei Xu, Martin Pilhofer, Susan Schlimpert   +7 more
doaj   +1 more source

Toward an Improved Meningococcal Serogroup B Assay

mBio, 2018
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is ...
Jan Poolman
doaj   +1 more source

A metagenomic assessment of the bacteria associated with Lucilia sericata and Lucilia cuprina (Diptera: Calliphoridae) [PDF]

, 2014
Lucilia Robineau-Desvoidy (Diptera: Calliphoridae) is a blow fly genus of forensic, medical, veterinary, and agricultural importance. This genus is also famous because of its beneficial uses in maggot debridement therapy (MDT).
Crippen, Tawni L, Dowd, Scot E, Fields, Andrew T, Flores, Micah, Ma, Qun, Singh, Baneshwar, Tarone, Aaron M, Tomberlin, Jeffery K, Wood, Thomas K, Yu, Ziniu, Zheng, Longyu   +10 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source