Results 71 to 80 of about 1,761,029 (289)

From pathogenesis to antigens: the key to shaping the future of TB vaccines

Frontiers in Immunology
Tuberculosis (TB) remains one of the gravest global health challenges. Mycobacterium tuberculosis (M. tuberculosis), the causative agent, employs sophisticated immune evasion and pathogenesis strategies.
Haoyan Yang, Haoyan Yang, Xinkui Lei, Xinkui Lei, Siyu Chai, Siyu Chai, Guimin Su, Guimin Su, Lin Du, Lin Du   +9 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Design of a Helicobacter pylori multi-epitope vaccine based on immunoinformatics

Frontiers in Immunology
Helicobacter pylori (H. pylori) is an infectious bacterium that colonizes the stomach of approximately half of the global population. It has been classified as a Group I carcinogen by the World Health Organization due to its strong association with an ...
Man Cui, Man Cui, Xiaohui Ji, Xiaohui Ji, Fengtao Guan, Fengtao Guan, Guimin Su, Guimin Su, Lin Du, Lin Du   +9 more
doaj   +1 more source

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]

, 2018
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika, Karaś, Magdalena, Lipa, Paulina, Vinardell González, José María   +3 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A multi-epitope vaccine incorporating adhesin-derived antigens protects against Mycobacterium tuberculosis infection and dissemination

Frontiers in Immunology
IntroductionAdhesion to host cells is the first and essential step in Mycobacterium tuberculosis (M. tuberculosis) infection. Among adhesion molecules, the PGRS domain of PE_PGRS33 plays a critical role in invasion but is dominated by B cell epitopes and
Haoyan Yang, Haoyan Yang, Xinkui Lei, Xinkui Lei, Siyu Chai, Siyu Chai, Sigen Zhang, Sigen Zhang, Guimin Su, Guimin Su, Lin Du, Lin Du   +11 more
doaj   +1 more source

Chronic dermatomycoses of the foot as risk factors for acute bacterial cellulitis of the leg: A case-control study [PDF]

, 2004
Objective: To assess the role of foot dermatomycosis ( tinea pedis and onychomycosis) and other candidate risk factors in the development of acute bacterial cellulitis of the leg.
Bardur Sigurgeirsson, Carle Paul, Dupuy A, Guberman D, Hans-Christian Korting, Helmut Kerl, Hull PR, Jean-Claude Roujeau, Roberts DT, Ronnen M, Sais G, Semel JD, Stulberg DL, Suss SJ   +13 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Immunogenicity of Glutaraldehyde Inactivated PTx Is Determined by the Quantity of Neutralizing Epitopes

Vaccines
Background/Objectives: Chemically or genetically detoxified pertussis toxin (PTx) is a crucial antigen component of the acellular pertussis vaccine. Chemical detoxification using glutaraldehyde generally causes significant structural changes to the toxin.
Xi Wang, Xinyue Cui, Chongyang Wu, Ke Tao, Shuyuan Pan, Wenming Wei   +5 more
doaj   +1 more source

Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli

Frontiers in Microbiology, 2019
In bacteria, the so-called stringent response is responsible for adaptation to changing environmental conditions. This response is mediated by guanosine derivatives [(p)ppGpp], synthesized by either large mono-functional RelA or bi-functional SpoT ...
Michał Sobala, Bożena Bruhn-Olszewska, Michael Cashel, Katarzyna Potrykus   +3 more
doaj   +1 more source