Results 171 to 180 of about 1,300,345 (298)

Comparison of extracellular vesicles carrying bacterial DNA in urine and serum from a Korean population. [PDF]

Front Microbiol
Yie GE, Kim NE, Park SC, Kim K, Shin S, Lee SK, Shin C, Lee KJ, Won S.   +8 more
europepmc   +1 more source

Developing novel antimicrobials by combining cancer chemotherapeutics with bacterial DNA repair inhibitors. [PDF]

PLoS Pathog, 2023
Bernacchia L, Gupta A, Paris A, Moores AA, Kad NM.   +4 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

The Difluoroboranyl-Fluoroquinolone Derivative "7a" Inhibits Bacterial DNA Gyrase and Exhibits Potent Activity Against Ciprofloxacin-Resistant <i>S. aureus</i> In Vitro and In Vivo Using an Acute Pneumonia Model. [PDF]

Molecules
Veyna-Hurtado LA, Hernández-López H, de Loera D, Vargas-Morales JM, Muñoz-Ortega M, Troncoso-Vázquez L, Bocanegra-Zapata A, Cervantes-Villagrana AR.   +7 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Responses to Ligand Binding in the Bacterial DNA Sliding Clamp "β-Clamp" Manifest in Dynamic Allosteric Effects. [PDF]

Proteins
Simonsen S, Prestel A, Østerlund EC, Otterlei M, Jørgensen TJD, Kragelund BB.   +5 more
europepmc   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Identification of clinically relevant profiles in colorectal cancer through integrated analysis of bacterial DNA and metabolome in serum. [PDF]

Front Immunol
Vicente-Valor J, Tesolato S, Gómez-Garre D, Paz-Cabezas M, Ortega-Hernández A, Fernández-Hernández C, de la Serna S, Domínguez-Serrano I, Dziakova J, Rivera D, Rupérez FJ, García A, Torres A, Iniesta P.   +13 more
europepmc   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Bacterial DNA Contamination of Commercial PCR Enzymes: Considerations for Microbiome Protocols and Analysis. [PDF]

Microorganisms
Skidmore AM, Bradfute SB.
europepmc   +1 more source