Results 11 to 20 of about 604,900 (351)

Modeling bacterial resistance to antibiotics: bacterial conjugation and drug effects [PDF]

Advances in Difference Equations, 2021
Antibiotic resistance is a major burden in many hospital settings as it drastically reduces the successful probability of treating bacterial infections.
Pirommas Techitnutsarut, Farida Chamchod
doaj   +2 more sources

Resisting Bacterial Drug Resistance [PDF]

Chemistry & Biology, 2003
In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
John S. Blanchard
openalex   +3 more sources

Defence against bacterial drug resistance. [PDF]

BMJ, 1976
Everyone knows that acquired microbic resistance is the Achilles heel of chemotherapy. All living things can acquire some resistance to noxious agents-man to morphine, for instance. Bacteria are no exception: they can become more resistant in some degree even to ordinary germicides.
L. P. Garrod
openalex   +4 more sources

State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review

Antibiotics, 2022
Resistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and
Hélène Meier, Keira Spinner, Lisa Crump, Esther Kuenzli, Gertraud Schuepbach, Jakob Zinsstag   +5 more
doaj   +1 more source

The Integration of Proteomics and Metabolomics Data Paving the Way for a Better Understanding of the Mechanisms Underlying Microbial Acquired Drug Resistance

Frontiers in Medicine, 2022
Due to an increase in the overuse of antimicrobials and accelerated incidence of drug resistant pathogens, antimicrobial resistance has become a global health threat.
Suereta Fortuin, Nelson C. Soares, Nelson C. Soares   +2 more
doaj   +1 more source

Co-expression of 16S rRNA Methyltransferase and Carbapenemase in Multidrug Resistant Gram Negative Bacteria [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: The drug resistance caused by bacteria has complicated the fight against the infectious diseases and recovery of the patients from the diseases.
Sandeep Kumar Tipparthi, Swathi Akula, HRV Rajkumar, A Ravishankar Reddy, Guru Prasad Manderwad   +4 more
doaj   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

Non-toxigenic Corynebacterium diphtheriae in hallux ulceration

Journal of Infection in Developing Countries, 2022
Introduction: Toxigenic Corynebacterium diphtheriae causes classical diphtheria. Skin infections by toxigenic or non-toxigenic Corynebacterium diphtheriae are prevalent in the tropics but are rarely reported.
Gauthier Delvallez, Edgar Badell, Sokleaph Cheng, Soda Meng, Vivandet Tong, Judy Norman, Julie Toubiana, Koen Vandelannoote, Anne-Laure Bañuls, Mallorie Hide, Sylvain Brisse   +10 more
doaj   +1 more source

Pharmacodynamic modelling of in vitro activity of tetracycline against a representative, naturally occurring population of porcine Escherichia coli [PDF]

, 2015
Background The complex relationship between drug concentrations and bacterial growth rates require not only the minimum inhibitory concentration but also other parameters to capture the dynamic nature of the relationship.
Agersø, Yvonne, Ahmad, Amais, Christiansen, Lasse Engbo, Damborg, Peter, Græsbøll, Kaare, Matthews, Louise, Nielsen, Søren Saxmose, Olsen, John Elmerdahl, Toft, Nils, Zachariasen, Camilla   +9 more
core   +4 more sources

Oxygen Limitation Enhances the Antimicrobial Activity of Fosfomycin in Pseudomonas aeruginosa Following Overexpression of glpT Which Encodes Glycerol-3-Phosphate/Fosfomycin Symporter

Frontiers in Microbiology, 2018
Fosfomycin is resurfacing as a “last resort drug” to treat infections caused by multidrug resistant pathogens. This drug has a remarkable benefit in that its activity increases under oxygen-limited conditions unlike other commonly used antimicrobials ...
Hidetada Hirakawa, Kumiko Kurabayashi, Koichi Tanimoto, Haruyoshi Tomita, Haruyoshi Tomita   +4 more
doaj   +1 more source