Results 101 to 110 of about 1,520,593 (361)

Hypoxia drives progression of multiple sclerosis by enhancing the inflammasome activation in macrophages with Porphyromonas gingivalis infection

Cell Death Discovery
Porphyromonas gingivalis (Pg), a gram-negative anaerobic bacterium, is a leading pathogen causing periodontitis. It secretes several virulence factors, including gingipains, lipopolysaccharides (LPS), and outer membrane vesicles (OMVs), which can trigger
Tokuju Okano, Hiroshi Ashida, Masayuki Tsukasaki, Tamako Iida, Masahiro Yamamoto, Hiroshi Takayanagi, Takeharu Sakamoto, Toshihiko Suzuki   +7 more
doaj   +1 more source

Hidden Burden of Bartonella quintana on the African Continent: Should the Bacterial Infection Be Considered a Neglected Tropical Disease? [PDF]

, 2023
Carl Boodman, Noah Fongwen, Alfonso Pecoraro, Adane Mihret, Hiwot Abayneh, Pierre‐Edouard Fournier, Nitin Gupta, Johan van Griensven   +7 more
openalex   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Tail assembly interference is a common strategy in bacterial antiviral defenses

Nature Communications
Many bacterial immune systems recognize phage structural components to activate antiviral responses, without inhibiting the function of the phage component.
Lingchen He, Laura Miguel-Romero, Jonasz B. Patkowski, Nasser Alqurainy, Eduardo P. C. Rocha, Tiago R. D. Costa, Alfred Fillol-Salom, José R. Penadés   +7 more
doaj   +1 more source

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Frontiers in Microbiology, 2018
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus, and the number of SFTS cases increased year by year in China. Previous studies had indicated that gut microbiome closely associated with
Honghai Xu, Honghai Xu, Honghai Xu, Yuanyuan Wei, Yuanyuan Wei, Hongqiu Ma, Yanyan Liu, Yalong Zhang, Lifen Hu, Lifen Hu, Jiabin Li, Jiabin Li   +11 more
doaj   +1 more source

Measures to eradicate multidrug-resistant organism outbreaks: How much does it cost? [PDF]

, 2015
This study aimed to assess the economic burden of infection control measures that succeeded in eradicating multidrug-resistant organisms (MDROs) in emerging epidemic contexts in hospital settings.
Birgand, GJC, Bourigault, C, Holmes, A, Iucet, JC, Lepelletier, D, Moore, L, Vella, V   +6 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

T-cell subpopulations αβ and γδ in cord blood of very preterm infants : The influence of intrauterine infection [PDF]

, 2013
Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedPreterm infants are very ...
A Kotiranta-Ainamo, Agata Serwatowska-Bargieł, B Mazur, BJ Stoll, C Cairo, C Koehler, C Nakasone, CL Langrish, DJ Sherman, DL Gibbons, E Juretic, Elżbieta Górska, ER Newton, F Jouen-Beades, G Locksmith, GA Follows, H Zaghouani, J Chipeta, L Marodi, M Snyder, Maria Katarzyna Kornacka, Maria Wąsik, N Xiong, NC Maxwell, PJ Duggan, R Romero, RA Polin, RL Goldenberg, RL Schelonka, Robert Kozarski, RS Baltimore, S Beetz, SC Rosa De, T Matsuoka, TA Moore, Y Konigshofer, Y Zhao   +36 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Assessing Membrane Fluidity and Visualizing Fluid Membrane Domains in Bacteria Using Fluorescent Membrane Dyes

Bio-Protocol, 2018
Membrane fluidity is a key parameter of bacterial membranes that undergoes quick adaptation in response to environmental challenges and has recently emerged as an important factor in the antibacterial mechanism of membrane-targeting antibiotics.
Michaela Wenzel, Norbert Vischer, Henrik Strahl, Leendert Hamoen   +3 more
doaj   +1 more source