Results 81 to 90 of about 4,641,320 (343)

Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

Clinical Infectious Diseases, 2019
Antimicrobial resistance has become one of the greatest threats to public health, with rising resistance to carbapenems being a particular concern due to the lack of effective and safe alternative treatment options.
Y. Doi
semanticscholar   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Direct RNA Sequencing Unfolds the Complex Transcriptome of Vibrio parahaemolyticus

mSystems, 2021
Conventional bacterial genome annotation provides information about coding sequences but ignores untranslated regions and operons. However, untranslated regions contain important regulatory elements as well as targets for many regulatory factors, such as
Mohamad Al kadi, Eiji Ishii, Dang Tat Truong, Daisuke Motooka, Shigeaki Matsuda, Tetsuya Iida, Toshio Kodama, Daisuke Okuzaki   +7 more
doaj   +1 more source

A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections

JAMA pediatrics, 2019
Importance In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications.
N. Kuppermann, P. Dayan, D. Levine, M. Vitale, L. Tzimenatos, M. Tunik, M. Saunders, M. Saunders, R. Ruddy, R. Ruddy, G. Roosevelt, A. Rogers, E. Powell, L. Nigrovic, J. Muenzer, J. Muenzer, J. Linakis, J. Linakis, K. Grisanti, D. Jaffe, J. Hoyle, J. Hoyle, R. Greenberg, Rajender K. Gattu, A. Cruz, E. Crain, D. Cohen, D. Cohen, A. Brayer, D. Borgialli, D. Borgialli, B. Bonsu, B. Bonsu, L. Browne, Stephen J. Blumberg, J. Bennett, S. Atabaki, J. Anders, E. Alpern, E. Alpern, Benjamin Miller, T. Casper, J. Dean, O. Ramilo, O. Ramilo, P. Mahajan, P. Mahajan   +46 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015

New Microbes and New Infections, 2017
Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya.
J. Njeru, H. Tomaso, K. Mertens, K. Henning, G. Wareth, R. Heller, S. Kariuki, E.M. Fèvre, H. Neubauer, M.W. Pletz   +9 more
doaj   +1 more source

Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections

Frontiers in Pharmacology, 2019
Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect on human or animal cells. For this reason, it is supposed that they can be used, alone or in combination with antibiotics, to treat bacterial infections.
N. Principi, Ettore Silvestri, S. Esposito   +2 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Global survey of mRNA levels and decay rates of Chlamydia trachomatis trachoma and lymphogranuloma venereum biovars

Heliyon, 2017
Interpreting the intricate bacterial transcriptomics implies understanding the dynamic relationship established between de novo transcription and the degradation of transcripts. Here, we performed a comparative overview of gene expression levels and mRNA
Rita Ferreira, Vítor Borges, Maria José Borrego, João Paulo Gomes   +3 more
doaj   +1 more source

Estrogen and bacterial infection

Frontiers in Immunology
Gender differences exist in the susceptibility, incidence, progression, and prognosis of bacterial infections in males and females, influenced by various factors including lifestyle and habits. Multiple reports have indicated that estrogen plays a crucial immunomodulatory role in many pathogenic microbial infections, highlighting a complex relationship
Longyan Hong, Longyan Hong, Hao Liang, Wenqing Man, Yinghui Zhao, Pengbo Guo, Pengbo Guo   +6 more
openaire   +3 more sources