Results 111 to 120 of about 199,924 (308)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

HUMAN HERPESVIRUS 8 UPREGULATES ACTIVATING TRANSCRIPTION FACTOR 4 (ATF4) and REAL TIME PCR TO ASSESS TOTAL BACTERIAL LOAD IN CHRONIC WOUNDS. [PDF]

, 2010
I. Human Herpesvirus 8 Upregulates Activator Transcription Factor 4 BACKGROUND: Human herpesvirus 8 (HHV-8) is the primary etiologic agent of Kaposi’s sarcoma, a highly vascularised neoplasm of endothelial origin characterized by inflammation ...
Gentili, Valentina
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The role of complex systems in the management of pervasive computing. [PDF]

, 2002
Network complexity will increase dramatically over the next 5 years as will the amount of devices inhabiting these networks. Ad-hoc and active paradigms will make the already onerous task of network management increasingly problematic.
Roadknight, Chris, Marshall, Ian W., Sacks, Lionel   +2 more
core  

Bacterial Loads in Moroccan Mussels from Harvest to Sale

Journal of Food Protection, 1995
This study concerns the seasonal variation of bacteria in seawater and mussels harvested from a Moroccan coastal area subject to clandestine shellfishing. The changes in the level of bacterial counts of mussels from harvest to sale are also presented. Both seawater and mussels showed regular increases in bacterial loads from fall to summer.
Nourredine, Bouchriti, Abdelhak El, Marrakchi, Sagar M, Goyal, Rachid, Boutaib   +3 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The role of airway infection in chronic obstructive pulmonary disease [PDF]

, 2006
PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core  

Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass-smoke COPD [PDF]

, 2018
Lower airway colonisation with potentially pathogenic bacterial species (PPBs) is associated with defective bacterial phagocytosis, in monocyte-derived macrophages (MDMs) and alveolar macrophages, from tobacco-smoke associated COPD (S-COPD) subjects.
Barnes, Peter J, Brashier, Bill, Juvekar, Sanjay, Gaike, Akshay H, Das, Vandana V, Londhe, Jyoti D, Ghosh, Baishakhi, Shouche, Yogesh S, Donnelly, Louise E, Salvi, Sundeep S, Pyasi, Kanchan   +10 more
core   +1 more source

Probiotic-Loaded Bacterial Cellulose as an Alternative to Combat Carbapenem-Resistant Bacterial Infections

Antibiotics
Background: Carbapenems are one of the mainstays of treatment for antibiotic-resistant bacteria (ARB). This has made the rise of carbapenem-resistant bacteria a threat to global health. In fact, the World Health Organization (WHO) has identified carbapenem-resistant bacteria as critical pathogens, and the development of novel antibacterials capable of ...
José Gutiérrez-Fernández, Laura Cerezo-Collado, Víctor Garcés, Pablo Alarcón-Guijo, José M. Delgado-López, Jose M. Dominguez-Vera   +5 more
openaire   +5 more sources

Variability and Determinants of Carcass Bacterial Load at a Poultry Abattoir

Journal of Food Protection, 1993
Roaster chicken carcasses (2,928) were collected from the evisceration line of a poultry abattoir over a 5-month period and identified as to the lot (truck load) and supplier. Bacterial load was determined by mechanically rinsing each eviscerated carcass in sterile water and then using an automated hydrophobic grid membrane interpreter system to obtain
Shane A, Renwick, W Bruce, McNab, H Ruffner, Lowman, Robert C, Clarke   +3 more
openaire   +2 more sources