Results 11 to 20 of about 1,259,375 (319)

Blood–Brain Barrier Integrity Damage in Bacterial Meningitis: The Underlying Link, Mechanisms, and Therapeutic Targets

International Journal of Molecular Sciences, 2023
Despite advances in supportive care and antimicrobial treatment, bacterial meningitis remains the most serious infection of the central nervous system (CNS) that poses a serious risk to life.
Ruicheng Yang, Jundan Wang, Fen Wang, Huipeng Zhang, Chen Tan, Huanchun Chen, Xiangru Wang   +6 more
semanticscholar   +1 more source

Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016

mBio, 2021
The impact of serogroup B meningococcal (MenB) vaccines on carriage is not completely understood. Using whole-genome sequencing data, we assessed the diversity and distribution of MenB vaccine antigens (particularly FHbp) among 1,514 meningococcal ...
Henju Marjuki, How-Yi Chang, Nadav Topaz, Melissa J. Whaley, Jeni Vuong, Alexander Chen, Laurel T. Jenkins, Fang Hu, Susanna Schmink, Adam C. Retchless, Jennifer D. Thomas, Anna M. Acosta, Lucy A. McNamara, Heidi M. Soeters, Sarah Mbaeyi, Xin Wang   +15 more
doaj   +1 more source

Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention

Microorganisms, 2021
Bacterial meningitis is a devastating infection, with a case fatality rate of up to 30% and 50% of survivors developing neurological complications. These include short-term complications such as focal neurological deficit and subdural effusion, and long ...
Abdulwahed Zainel, Hana Mitchell, M. Sadarangani   +2 more
semanticscholar   +1 more source

The Impact and Burden of Neurological Sequelae Following Bacterial Meningitis: A Narrative Review

Microorganisms, 2021
The burden, impact, and social and economic costs of neurological sequelae following meningitis can be devastating to patients, families and communities. An acute inflammation of the brain and spinal cord, meningitis results in high mortality rates, with
N. Schiess, N. Groce, T. Dua
semanticscholar   +1 more source

Neuronal Damage and Neuroinflammation, a Bridge Between Bacterial Meningitis and Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2021
Bacterial meningitis is an inflammation of the meninges which covers and protects the brain and the spinal cord. Such inflammation is mostly caused by blood-borne bacteria that cross the blood-brain barrier (BBB) and finally invade the brain parenchyma ...
Kristine Farmen, Miguel Tofiño-Vian, F. Iovino   +2 more
semanticscholar   +1 more source

Genetic Features of a Representative Panel of 110 Meningococcal B Isolates to Assess the Efficacy of Meningococcal B Vaccines

mSphere, 2022
Predictions of vaccine efficacy against Neisseria meningitidis serogroup B (NmB) disease are hindered by antigenic variability, limiting the representativeness of individual NmB isolates.
Alessandro Muzzi, Margherita Bodini, Nadav Topaz, Vega Masignani, Kumaran Vadivelu, Henju Marjuki, Xin Wang, Laura Serino, Duccio Medini   +8 more
doaj   +1 more source

Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children

Infectious Diseases and Therapy, 2023
Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections.
Weronika Puzia, Jan Gawor, Robert Gromadka, Karolina Żuchniewicz, Izabela Wróbel-Pawelczyk, Patrycja Ronkiewicz, Agnieszka Gołębiewska, Waleria Hryniewicz, Ewa Sadowy, Anna Skoczyńska   +9 more
doaj   +1 more source

Genomic Insights on Variation Underlying Capsule Expression in Meningococcal Carriage Isolates From University Students, United States, 2015–2016

Frontiers in Microbiology, 2022
In January and February 2015, Neisseria meningitidis serogroup B (NmB) outbreaks occurred at two universities in the United States, and mass vaccination campaigns using MenB vaccines were initiated as part of a public health response.
Melissa J. Whaley, Jeni T. Vuong, Nadav Topaz, How-Yi Chang, Jennifer Dolan Thomas, Laurel T. Jenkins, Fang Hu, Susanna Schmink, Evelene Steward-Clark, Marsenia Mathis, Lorraine D. Rodriguez-Rivera, Adam C. Retchless, Sandeep J. Joseph, Alexander Chen, Anna M. Acosta, Lucy McNamara, Heidi M. Soeters, Sarah Mbaeyi, Henju Marjuki, Xin Wang   +19 more
doaj   +1 more source

The Global Landscape of Pediatric Bacterial Meningitis Data Reported to the World Health Organization–Coordinated Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2014–2019

Journal of Infectious Diseases, 2021
Background The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use.
Tomoka Nakamura, A. Cohen, Stephanie B. Schwartz, J. Mwenda, G. Weldegebriel, J. Biey, R. Katsande, A. Ghoniem, K. Fahmy, Hossam Abdel Rahman, Dovile Videbaek, D. Daniels, Simarjit Singh, A. Wasley, G. Rey-Benito, L. D. de Oliveira, Claudia Ortiz, Emmanuel Tondo, J. Liyanage, Mohammad Sharifuzzaman, Varja Grabovac, N. Batmunkh, Josephine Logronio, J. Heffelfinger, K. Fox, L. De Gouveia, A. von Gottberg, M. du Plessis, B. Kwambana-Adams, M. Antonio, S. El Gohary, A. Azmy, A. Gamal, E. Voropaeva, E. Egorova, Y. Urban, C. Duarte, B. Veeraraghavan, S. Saha, B. Howden, M. Sait, S. Jung, S. Bae, D. Litt, S. Seaton, M. Slack, S. Antoni, Mahamoudou Ouattara, C. V. Van Beneden, F. Serhan   +49 more
semanticscholar   +1 more source

Changing Epidemiology of Bacterial Meningitis Since Introduction of Conjugate Vaccines: 3 Decades of National Meningitis Surveillance in The Netherlands

Clinical Infectious Diseases, 2020
Background The epidemiology of acute bacterial meningitis has changed substantially since the introduction of conjugate vaccines. Methods We analyzed nationwide surveillance data of all cerebrospinal fluid isolates received by the Netherlands Reference ...
D. Koelman, Merel N. van Kassel, M. Bijlsma, M. Brouwer, D. van de Beek, A. van der Ende   +5 more
semanticscholar   +1 more source