Results 11 to 20 of about 1,029,387 (219)

A Chiral Virus-Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy. [PDF]

Adv Sci (Weinh)
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Xu Q, Zheng X, Tong H, Liu Y, Fan X, Xu M, Zhang Z, Zhang L, Liu M, Du T, Li H, Liu G.   +11 more
europepmc   +2 more sources

Bacterial Meningitis [PDF]

, 2021
This timely collection of expert papers draws attention to the global burden of meningitis and the challenges faced by the WHO’s roadmap to defeat meningitis by 2030.
Haroon, Raihanah
core   +2 more sources

Bacterial meningitis: the role of transforming growth factor-Beta in innate immunity and secondary brain damage [PDF]

, 2007
Project 6 of the NCCR 'Neural Plasticity and Repair' focuses on mechanisms of immunity and tissue damage in autoimmune and infectious diseases of the central nervous system (CNS).
Malipiero, U, Malipiero, Ursula, Pfister, W, Fontana, Adriano, Koedel, U, Pfister, Walter, Fontana, A, Koedel, Uwe, Pfister W, Fontana A, Koedel U, Malipiero U   +11 more
core   +1 more source

The age-related risk of co-existing meningitis in children with urinary tract infection [PDF]

, 2011
Objective: The primary aim of this study was to determine age-stratified rates of co-existing bacterial meningitis in children with urinary tract infection (UTI).
Clifford Vanessa, Tebruegge Marc, Nigel Curtis, Tebruegge, M, Marc Tebruegge, Connell Tom, Connell, Tom, Gonis, Gena, Clifford, V, Ritz, N, Curtis, N, Curtis, Nigel, Gonis Gena, Pantazidou, Anastasia, Clifford, Vanessa, Ritz Nicole, Curtis Nigel, Pantazidou, A, Ritz, Nicole, Gena Gonis, Tom Connell, Anastasia Pantazidou, Vanessa Clifford, Nicole Ritz, Connell, T, Tebruegge, Marc, Pantazidou Anastasia, Gonis, G   +27 more
core   +2 more sources

Meningococcal and pneumococcal meningitis in Northern Ghana [PDF]

, 2008
Despite improvements in technology, treatments and understanding of how bacterial meningitis develops, the disease remains a potentially life-threatening emergency capable of causing significant morbidity and mortality. N. meningitidis, S.
Forgor, Abdulai Adams
core   +1 more source

Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. [PDF]

, 2009
During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages.
Häcker Georg, Bianca Obermaier, Georg Häcker, Robert Paul, Hans Häcker, Obermaier, Bianca, Paul Robert, Frankenberg, Tobias, Koedel, Uwe, Uwe Koedel, Frankenberg Tobias, Paul, Robert, Susanne Kirschnek, Kirschnek, Susanne, Tobias Frankenberg, Kirschnek Susanne, Obermaier Bianca, Koedel Uwe, Häcker, Hans, Häcker, Georg, Häcker Hans, Koedel, U;Frankenberg, T;Kirschnek, S;Obermaier, B;Häcker, H;Paul, R;Häcker, G   +21 more
core   +2 more sources

Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. [PDF]

, 2010
BACKGROUND: The presentation and causes of adult meningitis in South Africa have changed substantially as a result of HIV. Knowledge of aetiology and laboratory findings in patients presenting with meningitis are important in guiding management.
Crede Tom, Williams, A, Thomas S Harrison, Meintjes, Graeme, Brown Yolande, Harrison Thomas S, Jarvis, Joseph, Yolande Brown, Tom Crede, Joseph N Jarvis, Jarvis, JN, Meintjes Graeme, Harrison, Thomas, Crede, Tom, Anthony Williams, Jarvis Joseph N, Harrison, Thomas S, Brown, Y, Brown, Yolande, Harrison, TS, Crede, T, Williams, Anthony, Graeme Meintjes, Williams Anthony, Meintjes, G, Jarvis, Joseph N   +25 more
core   +2 more sources

Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.

PLoS ONE, 2021
ObjectivesMeningitis is a medical emergency with permanent disabilities and high mortality worldwide. We aimed to determine causative microorganisms and potential markers for differentiation between bacterial and viral meningitis.MethodologyAdult ...
Sultan F Alnomasy, Bader S Alotaibi, Ahmed H Mujamammi, Elham A Hassan, Mohamed E Ali   +4 more
doaj   +1 more source

A machine learning approach to differentiating bacterial from viral meningitis [PDF]

, 2006
Clinical reports indicate that differentiating bacterial from viral (aseptic) meningitis is still a difficult issue, compounded by factors such as age and time of presentation.
M. Ene, K. Revett, Revett, K., Ene, M., Gorunescu, F., F. Gorunescu, Gorunescu, M.   +6 more
core   +1 more source

Phylogenetic relationships and regional spread of meningococcal strains in the meningitis belt, 2011–2016Research in context

EBioMedicine, 2019
Background: Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogroup A ...
Nadav Topaz, Dominique A. Caugant, Muhamed-Kheir Taha, Ola Brønstad Brynildsrud, Nadia Debech, Eva Hong, Ala-Eddine Deghmane, Rasmata Ouédraogo, Sani Ousmane, Kadidja Gamougame, Berthe-Marie Njanpop-Lafourcade, Seydou Diarra, LeAnne M. Fox, Xin Wang   +13 more
doaj   +1 more source