Results 151 to 160 of about 142,532 (273)

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

The Crystal Structure of the Outer Membrane Protein VceC from the Bacterial Pathogen Vibrio cholerae at 1.8 Å Resolution [PDF]

, 2005
L. Federici, Dijun Du, Fabien Walas, Hiroyoshi Matsumura, Juan Fernández‐Recio, Kenneth Scott McKeegan, M. Inês Borges‐Walmsley, Ben F. Luisi, Adrian R. Walmsley   +8 more
openalex   +1 more source

In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

, 2021
Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R. Wood, Catherine M. Oikonomou, William J. Nicolas, Poorna Subramanian, Lori Zacharoff, Yuhang Wang, Yi‐Wei Chang, Morgan Beeby, Megan J. Dobro, Yongtao Zhu, Mark J. McBride, Ariane Briegel, Carrie L. Shaffer, Grant J. Jensen   +17 more
openalex   +1 more source

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source

From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party. [PDF]

FEMS Microbiol Rev
Osset-Trenor P, Proft M, Pascual-Ahuir A.   +2 more
europepmc   +1 more source

The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition. [PDF]

J Biol Chem, 2018
Hussain S, Bernstein HD.
europepmc   +1 more source

Intrinsically Disordered Protein Threads Through the Bacterial Outer-Membrane Porin OmpF

, 2013
Nicholas G. Housden, Jonathan T. S. Hopper, Natalya Lukoyanova, David Rodríguez‐Larrea, J.A. Wojdyla, Alexander Klein, Renata Kaminska, Hagan Bayley, Helen R. Saibil, Carol V. Robinson, Colin Kleanthous   +10 more
openalex   +2 more sources

Salmonella Typhimurium outer membrane protein A (OmpA) renders protection from nitrosative stress of macrophages by maintaining the stability of bacterial outer membrane

, 2022
Atish Roy Chowdhury, Shivjee Sah, Umesh Varshney, Dipshikha Chakravortty   +3 more
openalex   +2 more sources

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source