Gout and NLRP3 Inflammasome Biology
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Development of Broad-Spectrum Antimicrobial Peptides through the Conjugation of FtsZ-Binding and Cell-Penetrating Peptides. [PDF]
Du RL+8 more
europepmc +1 more source
Metal‐Mediated Protein Engineering within Live Cells
This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
wiley +1 more source
The lipoprotein transport system (Lol) is a crucial target for combating multidrug‐resistant gram‐negative bacteria. This review discusses the structural and functional aspects of the LolABCDE complex, recent advances in small‐molecule inhibitors, and challenges, such as permeability and resistance.
Saemee Song, Su Yong Shim
wiley +1 more source
The polyamino-isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi-target inhibitors against the ESKAPEE bacterium <i>Enterobacter cloacae</i>. [PDF]
Forest E+11 more
europepmc +1 more source
Genome-wide investigation of outer membrane protein families under mosaic evolution in <i>Escherichia coli</i>. [PDF]
Cao X+13 more
europepmc +1 more source
Multisite binding of bacteriophages on lipopolysaccharides in <i>Escherichia coli</i> O157:H7 and the adaptive costs of phage resistance. [PDF]
Wang Y+9 more
europepmc +1 more source
Bacterial Extracellular Vesicles and Antimicrobial Peptides: A Synergistic Approach to Overcome Antimicrobial Resistance. [PDF]
Ciobanasu C.
europepmc +1 more source