Results 281 to 290 of about 358,692 (311)
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Modeling and simulation of bacterial outer membranes and interactions with membrane proteins.
Current Opinion in Structural Biology, 2017The outer membrane (OM) of Gram-negative bacteria is composed of phospholipids in the periplasmic leaflet and lipopolysaccharides (LPS) in the external leaflet, along with β-barrel OM proteins (OMPs) and lipidated periplasmic lipoproteins. As a defensive barrier to toxic compounds, an LPS molecule has high antigenic diversity and unique combination of ...
Dhilon S. Patel, Yifei Qi, W. Im
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Assembly of bacterial outer membrane proteins.
Methods in molecular biology, 2013Various methods that are routinely used to study the subcellular localization of membrane proteins in wild-type Gram-negative bacteria fall short in genetic studies addressing the biogenesis of outer membrane proteins (OMPs). Here, we describe three biochemical methods that can be used in such studies to evaluate the proper assembly of OMPs into the ...
J. Grijpstra, M. Bos, J. Tommassen
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Export and assembly of bacterial outer membrane proteins
Antonie van Leeuwenhoek, 1992J. Tommassen, M. Struyvé, H. Cock
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Analysis of bacterial outer membrane proteins.
Methods in molecular biology, 1995H. Chart
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Protein import and export across the bacterial outer membrane
Current Opinion in Structural Biology, 2021The bacterial outer membrane forms an impermeable barrier to the environment, but a wide variety of substances must cross it without compromising the membrane. Perhaps, the most fascinating transport phenomenon is the import and export of very large protein toxins using relatively small β-barrel proteins residing in the outer membrane.
Jérémy, Guérin, Susan K, Buchanan
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Host immunity and cellular responses to bacterial outer membrane vesicles.
Trends in immunology, 2021All Gram-negative bacteria produce outer membrane vesicles (OMVs) which are minute spherical structures emanating from the bacterial outer membrane. OMVs are primarily enriched in lipopolysaccharide (LPS) and phospholipids, as well as outer membrane and ...
Varnesh Tiku, M. Tan
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Protein oligomerization in the bacterial outer membrane (Review)
Molecular Membrane Biology, 2009The formation of homo-oligomeric assemblies is a well-established characteristic of many soluble proteins and enzymes. Oligomerization has been shown to increase protein stability, allow allosteric cooperativity, shape reaction compartments and provide multivalent interaction sites in soluble proteins. In comparison, our understanding of the prevalence
Guoyu, Meng +4 more
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Bacterial outer membrane vesicles and host cell death signaling.
Trends in Microbiology, 2021The programmed cell death pathways of pyroptosis and apoptosis protect mammals from infections. The activation of host cell death signaling depends on cell surface and cytosolic receptors that bind bacterial molecules or sense their activity.
Subhash Dhital +3 more
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Structural Aspects of Bacterial Outer Membrane Protein Assembly
2015The outer membrane of Gram-negative bacteria is predominantly populated by β-Barrel proteins and lipid anchored proteins that serve a variety of biological functions. The proper folding and assembly of these proteins is essential for bacterial viability and often plays a critical role in virulence and pathogenesis. The β-barrel assembly machinery (Bam)
Charles, Calmettes +2 more
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Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence
Trends in Biochemical Sciences, 2017Methylation of outer membrane proteins (OMPs) has been implicated in bacterial virulence. Lysine methylation in rickettsial OmpB is correlated with rickettsial virulence, and N- and O-methylations are also observed in virulence-relevant OMPs from several pathogenic bacteria that cause typhus, leptospirosis, tuberculosis, and anaplasmosis.
David C H, Yang +4 more
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