Results 31 to 40 of about 698,346 (166)

Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs

EMBO Reports
Bacteria have evolved numerous biochemical processes that underpin their biology and pathogenesis. The small, non-enzymatic bacterial (Salmonella) effector SteE mediates kinase reprogramming, whereby the canonical serine/threonine host kinase GSK3 gains ...
Ioanna Panagi, Janina H Muench, Alexi Ronneau, Ines Diaz-del-Olmo, Agnel Aliyath, Xiu-Jun Yu, Hazel Mak, Enkai Jin, Jingkun Zeng, Diego Esposito, Elliott Jennings, Timesh D Pillay, Regina A Günster, Sarah L Maslen, Katrin Rittinger, Teresa L M Thurston   +15 more
doaj   +1 more source

Klebsiella pneumoniae, a human-dog shuttle organism for the genes of CTX-M ESBL

Scientific Reports
Antimicrobials reserved for human medicines are permitted for companion animals and it is important to understand multidrug-resistant pathogens recovered from companion animals in terms of epidemiological correlation with human pathogens and possibility ...
Eun-Jeong Yoon, You Jeong Choi, Dongju Won, Jong Rak Choi, Seok Hoon Jeong   +4 more
doaj   +1 more source

Host-induced cell wall remodeling impairs opsonophagocytosis of Staphylococcus aureus by neutrophils

mBio
The bacterial pathogen Staphylococcus aureus responds to the host environment by increasing the thickness of its cell wall. However, the impact of cell wall thickening on susceptibility to host defenses is unclear. Using bacteria incubated in human serum,
Elizabeth V. K. Ledger, Andrew M. Edwards   +1 more
doaj   +1 more source

Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites

Nature Communications, 2023
The intestine is the primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and serves as a reservoir of CRE that cause invasive infections (e.g. bloodstream infections).
Alexander Y. G. Yip, Olivia G. King, Oleksii Omelchenko, Sanjana Kurkimat, Victoria Horrocks, Phoebe Mostyn, Nathan Danckert, Rohma Ghani, Giovanni Satta, Elita Jauneikaite, Frances J. Davies, Thomas B. Clarke, Benjamin H. Mullish, Julian R. Marchesi, Julie A. K. McDonald   +14 more
doaj   +1 more source

Prevalence of Plasmid-Mediated Determinants With Decreased Susceptibility to Azithromycin Among Shigella Isolates in Anhui, China

Frontiers in Microbiology, 2020
ObjectiveThe aims of this study were to describe azithromycin (AZM) susceptibility patterns among Shigella isolates in Anhui, China and identify predictors of resistance with mobile element-mediated genes.MethodsA total of 517 non-duplicate Shigella ...
Yanyan Liu, Yanyan Liu, Yanyan Liu, Hongru Li, Na Lv, Yalong Zhang, Xihai Xu, Ying Ye, Ying Ye, Ying Ye, Yufeng Gao, Yufeng Gao, Yufeng Gao, Jiabin Li, Jiabin Li, Jiabin Li, Jiabin Li   +16 more
doaj   +1 more source

Prevalence and Molecular Epidemiology of Extended-Spectrum-β-Lactamase (ESBL)-Producing Escherichia coli from Multiple Sectors of Poultry Industry in Korea

Antibiotics, 2021
The aim of this study was to investigate the molecular epidemiology of extended-spectrum-β-lactamase producing Escherichia coli (ESBL-EC) from poultry, the poultry farm environment, and workers in Korea.
Hyunsoo Kim, Young Ah Kim, Young Hee Seo, Hyukmin Lee, Kyungwon Lee   +4 more
doaj   +1 more source

Identification of novel genetic factors that regulate c-di-AMP production in Staphylococcus aureus using a riboswitch-based biosensor

mSphere
Nucleotide secondary messengers regulate various processes in bacteria allowing them to rapidly respond to changes in environmental conditions. c-di-AMP is an essential second messenger required for the growth of the human pathogen Staphylococcus aureus,
Igor Kviatkovski, Qiyun Zhong, Sanika Vaidya, Angelika Gründling   +3 more
doaj   +1 more source

Nicorandil reduces the antimicrobial effectiveness of polymyxin E against Klebsiella pneumoniae by decreasing reactive oxygen species accumulation

Frontiers in Cellular and Infection Microbiology
Nitric oxide (NO) plays a crucial role in bacterial physiology and survival, particularly in relation to antibiotic resistance. The protective role of NO against antibiotics is intricate, and the potential antagonistic interactions between NO donors and ...
Rongqing Zhu, Fangxin Luo, Chenxi Yuan, Ziqian Fang, Yaqin Guo, Bao Meng, Dongmei Zhao, Yanyan Liu, Yanyan Liu, Yanyan Liu, Yi Yang, Yi Yang, Yi Yang, Yasheng Li, Yasheng Li, Yasheng Li, Jiabin Li, Jiabin Li, Jiabin Li, Liang Yu, Liang Yu, Liang Yu   +21 more
doaj   +1 more source

Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection

Journal of Nanobiotechnology
Bacterial cystitis, a commonly occurring urinary tract infection (UTI), is renowned for its extensive prevalence and tendency to recur. Despite the extensive utilization of levofloxacin as a conventional therapeutic approach for bacterial cystitis, its ...
Yi Yang, Guang-Wei Yang, Jian-Juan Lu, Hao-Ran Chen, Ya-Qin Guo, Ning Yang, Yun-Zhu Zhu, Xiao-Qiang Liu, Ting-Ting Su, Yan-Yan Liu, Liang Yu, Ya-Sheng Li, Li-Fen Hu, Jia-Bin Li   +13 more
doaj   +1 more source

Designing phage cocktails to combat the emergence of bacteriophage-resistant mutants in multidrug-resistant Klebsiella pneumoniae

Microbiology Spectrum
Phage therapy, an emerging strategy in the fight against recalcitrant bacterial infections, encounters a significant hurdle posed by the development of phage-resistant bacterial strains. To address this concern, we suggest a novel phage cocktail.
Seongjun Yoo, Kang-Mu Lee, Nayoung Kim, Thao Nguyen Vu, Ricardo Abadie, Dongeun Yong   +5 more
doaj   +1 more source