Results 61 to 70 of about 3,624,305 (255)

Transferable drug resistance plasmids in fish-pathogenic bacteria [PDF]

, 2000
Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core   +1 more source

Designing phage cocktails to combat the emergence of bacteriophage-resistant mutants in multidrug-resistant Klebsiella pneumoniae

Microbiology Spectrum
Phage therapy, an emerging strategy in the fight against recalcitrant bacterial infections, encounters a significant hurdle posed by the development of phage-resistant bacterial strains. To address this concern, we suggest a novel phage cocktail.
Seongjun Yoo, Kang-Mu Lee, Nayoung Kim, Thao Nguyen Vu, Ricardo Abadie, Dongeun Yong   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection

Journal of Nanobiotechnology
Bacterial cystitis, a commonly occurring urinary tract infection (UTI), is renowned for its extensive prevalence and tendency to recur. Despite the extensive utilization of levofloxacin as a conventional therapeutic approach for bacterial cystitis, its ...
Yi Yang, Guang-Wei Yang, Jian-Juan Lu, Hao-Ran Chen, Ya-Qin Guo, Ning Yang, Yun-Zhu Zhu, Xiao-Qiang Liu, Ting-Ting Su, Yan-Yan Liu, Liang Yu, Ya-Sheng Li, Li-Fen Hu, Jia-Bin Li   +13 more
doaj   +1 more source

Antimicrobial Resistance, Genetic Diversity and Multilocus Sequence Typing of Escherichia coli from Humans, Retail Chicken and Ground Beef in Egypt

Pathogens, 2020
Contamination of retail foods with foodborne pathogens, particularly the antimicrobial resistant ones, poses a persistent threat to human health. There is a dearth of information about the overlapping Escherichia coli (E. coli) lineages circulating among
Hazem Ramadan, Charlene R. Jackson, Jonathan G. Frye, Lari M. Hiott, Mohamed Samir, Amal Awad, Tiffanie A. Woodley   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Nicorandil reduces the antimicrobial effectiveness of polymyxin E against Klebsiella pneumoniae by decreasing reactive oxygen species accumulation

Frontiers in Cellular and Infection Microbiology
Nitric oxide (NO) plays a crucial role in bacterial physiology and survival, particularly in relation to antibiotic resistance. The protective role of NO against antibiotics is intricate, and the potential antagonistic interactions between NO donors and ...
Rongqing Zhu, Fangxin Luo, Chenxi Yuan, Ziqian Fang, Yaqin Guo, Bao Meng, Dongmei Zhao, Yanyan Liu, Yanyan Liu, Yanyan Liu, Yi Yang, Yi Yang, Yi Yang, Yasheng Li, Yasheng Li, Yasheng Li, Jiabin Li, Jiabin Li, Jiabin Li, Liang Yu, Liang Yu, Liang Yu   +21 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source