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Bacterial Defense against the Type VI Secretion System
Trends in Microbiology, 2021Bacteria have evolved systems dedicated to interbacterial competition. Here we highlight defenses utilized by Gram-negative cells against type VI secretion system (T6SS)-wielding competitors, including physical barriers, genetically encoded antidotes, and stress responses.
Sophie, Robitaille +2 more
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CryoEM of bacterial secretion systems
Current Opinion in Structural Biology, 2018The need for bacteria to interact with their environment has driven the evolution of elaborate secretion systems. By virtue of their function, secretion systems are macromolecular complexes associated with the cell envelope and therefore inherently difficult to study by conventional structural biology techniques.
Romain Kooger +3 more
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Redefining the bacterial Type I protein secretion system
2023Type I secretion systems (T1SS) are versatile molecular machines for protein transport across the Gram-negative cell envelope. The archetypal Type I system mediates secretion of the Escherichia coli hemolysin, HlyA. This system has remained the pre-eminent model of T1SS research since its discovery.
Freya J, Hodges +4 more
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Protein secretion systems in bacterial pathogens
Frontiers in Biology, 2014Many bacterial pathogens utilize specialized secretion systems to deliver virulence factors into the extracellular milieu. These exported effectors act to manipulate various processes of targeted cells in order to create a suitable niche for bacterial growth.
Li Xu, Yancheng Liu
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Structural Biology of Bacterial Type IV Secretion Systems
Annual Review of Biochemistry, 2015Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein–DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu
Vidya, Chandran Darbari +1 more
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Molecular architecture of bacterial type IV secretion systems
Trends in Biochemical Sciences, 2010In Gram-negative bacteria, type IV secretion (T4S) systems form ATP-powered complexes that span the entire cellular envelope and secrete a wide variety of substrates from single proteins to protein-protein and protein-DNA complexes. Recent structural data, namely the electron microscopy structure of the T4S core complex and the atomic-resolution ...
Gabriel, Waksman, Rémi, Fronzes
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Using Cryo-EM to Investigate Bacterial Secretion Systems
Annual Review of Microbiology, 2018Bacterial secretion systems are responsible for releasing macromolecules to the extracellular milieu or directly into other cells. These membrane complexes are associated with pathogenicity and bacterial fitness. Understanding of these large assemblies has exponentially increased in the last few years thanks to electron microscopy.
Rapisarda, Chiara +3 more
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Antivirulence drugs to target bacterial secretion systems
Current Opinion in Microbiology, 2010The rise of resistance of pathogenic bacteria to antibiotics constitutes an increasing risk to public health. Environmental bacteria constitute a large reservoir of resistance determinants and it is predictable that resistance to more antibiotics will be acquired by even more pathogens in future.
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