Results 11 to 20 of about 168,620 (156)
Named entity recognition for bacterial Type IV secretion systems. [PDF]
PLoS ONE, 2011 Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names.
Sophia Ananiadou +9 more
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Bacterial Secretion Systems: An Overview. [PDF]
Microbiol Spectr, 2016 ABSTRACT Bacterial pathogens utilize a multitude of methods to invade mammalian hosts, damage tissue sites, and thwart the immune system from responding. One essential component of these strategies for many bacterial pathogens is the secretion of proteins across phospholipid membranes.
Green ER, Mecsas J.
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Electron Cryotomography of Bacterial Secretion Systems. [PDF]
Microbiol Spectr, 2019 ABSTRACT In biology, function arises from form. For bacterial secretion systems, which often span two membranes, avidly bind to the cell wall, and contain hundreds of individual proteins, studying form is a daunting task, made possible by electron cryotomography (ECT).
Oikonomou CM, Jensen GJ.
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Identity Determinants of the Translocation Signal for a Type 1 Secretion System
Frontiers in Physiology, 2022 The toxin hemolysin A was first identified in uropathogenic E. coli strains and shown to be secreted in a one-step mechanism by a dedicated secretion machinery.
Olivia Spitz +10 more
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Bacterial secretion systems and regulation of inflammasome activation.
J Leukoc Biol, 2017 AbstractInnate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram-negative bacteria can exhibit specialized nanomachine secretion systems for delivery of effector proteins into mammalian cells.
Ratner D, Orning MP, Lien E.
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Secrete or perish: The role of secretion systems in Xanthomonas biology
Computational and Structural Biotechnology Journal, 2021 Bacteria of the Xanthomonas genus are mainly phytopathogens of a large variety of crops of economic importance worldwide. Xanthomonas spp. rely on an arsenal of protein effectors, toxins and adhesins to adapt to the environment, compete with other ...
Cristina E. Alvarez-Martinez +7 more
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The versatile bacterial type IV secretion systems [PDF]
Nature Reviews Microbiology, 2003 Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis--genetic exchange and the delivery of effector molecules to eukaryotic target cells. Whereas gene acquisition is an important adaptive mechanism that enables pathogens to cope with a changing environment during invasion of the host, interactions between ...
Cascales, E., Christie, Peter
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The regulation of bacterial two‐partner secretion systems
Molecular Microbiology, 2023 AbstractTwo‐partner secretion (TPS) systems, also known as Type Vb secretion systems, allow the translocation of effector proteins across the outer membrane of Gram‐negative bacteria. By secreting different classes of effectors, including cytolysins and adhesins, TPS systems play important roles in bacterial pathogenesis and host interactions. Here, we
Trouillon, Julian +2 more
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Developing Gram-negative bacteria for the secretion of heterologous proteins
Microbial Cell Factories, 2018 Gram-negative bacteria are attractive hosts for recombinant protein production because they are fast growing, easy to manipulate, and genetically stable in large cultures. However, the utility of these microbes would expand if they also could secrete the
Lisa Ann Burdette +3 more
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Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus. [PDF]
PLoS ONE, 2012 A growing number of pathogens are being found to possess specialized secretion systems which they use in various ways to subvert host defenses. Type IV secretion system (T4SS) is one of versatile secretion systems essential for the virulence and even ...
Wen Zhang +3 more
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