Results 31 to 40 of about 168,620 (156)

Primary architecture and energy requirements of Type III and Type IV secretion systems

Frontiers in Cellular and Infection Microbiology, 2023
Many pathogens use Type III and Type IV protein secretion systems to secrete virulence factors from the bacterial cytosol into host cells. These systems operate through a one-step mechanism. The secreted substrates (protein or nucleo-protein complexes in
Elena Cabezón, Fernando Valenzuela-Gómez, Ignacio Arechaga   +2 more
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Bacterial type IV secretion systems in human disease [PDF]

Molecular Microbiology, 2009
SummaryType IV secretion (T4S) systems are versatile machines involved in many processes relevant to bacterial virulence, such as horizontal DNA transfer and effector translocation into human cells. A recent workshop organized by the International University of Andalousia in Baeza, Spain, covered most aspects of bacterial T4S relevant to human disease,
Llosa, M., Roy, C., Dehio, C.
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Weaving of bacterial cellulose by the Bcs secretion systems [PDF]

FEMS Microbiology Reviews, 2021
ABSTRACT Cellulose is the most abundant biological compound on Earth and while it is the predominant building constituent of plants, it is also a key extracellular matrix component in many diverse bacterial species. While bacterial cellulose was first described in the 19th century, it was not until this last decade that a string of ...
Wiem Abidi, Lucía Torres-Sánchez, Axel Siroy, Petya Violinova Krasteva   +3 more
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Identification of protein secretion systems in bacterial genomes [PDF]

Scientific Reports, 2015
Abstract Bacteria with two cell membranes (diderms) have evolved complex systems for protein secretion. These systems were extensively studied in some model bacteria, but the characterisation of their diversity has lagged behind due to lack of standard annotation tools. We built online and standalone computational
Abby, Sophie S., Cury, Jean, Guglielmini, Julien, Néron, Bertrand, Touchon, Marie, Rocha, Eduardo P. C.   +5 more
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Regulation of Protein Secretion Systems Mediated by Cyclic Diguanylate in Plant-Interacting Bacteria

Frontiers in Microbiology, 2019
The ubiquitous second messenger cyclic diguanylate (c-di-GMP) is involved in the regulation of different processes in bacteria. In phytopathogens, intracellular fluctuations in the concentration of this molecule contribute to the lifestyle switching from
Francisco Javier López-Baena, Jose María Vinardell, Carlos Medina   +2 more
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In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center

mBio, 2021
Bacterial type IV secretion systems (T4SSs) play central roles in antibiotic resistance spread and virulence. By cryo-electron tomography (CryoET), we solved the structure of the plasmid pKM101-encoded T4SS in the native context of the bacterial cell ...
Pratick Khara, Liqiang Song, Peter J. Christie, Bo Hu   +3 more
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Species-specific components of the Helicobacter pylori Cag type IV secretion system

Infection and Immunity
Helicobacter pylori strains containing the cag pathogenicity island (PAI) deliver an effector protein (CagA) and non-protein substrates into gastric cells through a process that requires the Cag type IV secretion system (T4SS).
Kaeli N. Bryant, Arwen E. Frick-Cheng, Lauren E. Solecki, Heather K. Kroh, W. Hayes McDonald, D. Borden Lacy, Mark S. McClain, Melanie D. Ohi, Timothy L. Cover   +8 more
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Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.

PLoS Pathogens, 2008
The immune system must discriminate between pathogenic and nonpathogenic microbes in order to initiate an appropriate response. Toll-like receptors (TLRs) detect microbial components common to both pathogenic and nonpathogenic bacteria, whereas Nod-like ...
Sunny Shin, Christopher L Case, Kristina A Archer, Catarina V Nogueira, Koichi S Kobayashi, Richard A Flavell, Craig R Roy, Dario S Zamboni   +7 more
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Bacterial killing via a type IV secretion system [PDF]

Nature Communications, 2015
Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein-DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. Many bacteria of the family Xanthomonadaceae, which occupy diverse environmental niches, carry a T4SS with unknown function but ...
Diorge P, Souza, Gabriel U, Oka, Cristina E, Alvarez-Martinez, Alexandre W, Bisson-Filho, German, Dunger, Lise, Hobeika, Nayara S, Cavalcante, Marcos C, Alegria, Leandro R S, Barbosa, Roberto K, Salinas, Cristiane R, Guzzo, Chuck S, Farah   +11 more
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Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action

Antibodies, 2019
The mechanisms underlying the effects of immunoglobulins on bacterial infections are thought to involve bacterial cell lysis via complement activation, phagocytosis via bacterial opsonization, toxin neutralization, and antibody-dependent cell-mediated ...
Teiji Sawa, Mao Kinoshita, Keita Inoue, Junya Ohara, Kiyoshi Moriyama   +4 more
doaj   +1 more source