Bacteria-Killing Type IV Secretion Systems
Frontiers in Microbiology, 2019 Bacteria have been constantly competing for nutrients and space for billions of years. During this time, they have evolved many different molecular mechanisms by which to secrete proteinaceous effectors in order to manipulate and often kill rival ...
Germán G. Sgro +10 more
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Molecular Mechanisms of Bacterial Virulence: Type III Secretion and Pathogenicity Islands
Emerging Infectious Diseases, 1996 Recently, two novel but widespread themes have emerged in the field of bacterial virulence: type III secretion systems and pathogenicity islands. Type III secretion systems, which are found in various gram-negative organisms, are specialized for the ...
Joan Mecsas, Evelyn J. Strauss
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Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling. [PDF]
PLoS Pathogens, 2013 Bacterial pathogens utilize pore-forming toxins or sophisticated secretion systems to establish infection in hosts. Recognition of these toxins or secretion system by nucleotide-binding oligomerization domain leucine-rich repeat proteins (NLRs) triggers ...
Naomi Higa +8 more
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Bacterial protein secretion systems: Game of types.
Microbiology (Reading, England), 2022 Protein trafficking across the bacterial envelope is a process that contributes to the organisation and integrity of the cell. It is the foundation for establishing contact and exchange between the environment and the cytosol. It helps cells to communicate with one another, whether they establish symbiotic or competitive behaviours.
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Super-Resolution Imaging of Protein Secretion Systems and the Cell Surface of Gram-Negative Bacteria
Frontiers in Cellular and Infection Microbiology, 2017 Gram-negative bacteria have a highly evolved cell wall with two membranes composed of complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids.
Sachith D. Gunasinghe +4 more
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T346Hunter: a novel web-based tool for the prediction of type III, type IV and type VI secretion systems in bacterial genomes. [PDF]
PLoS ONE, 2015 T346Hunter (Type Three, Four and Six secretion system Hunter) is a web-based tool for the identification and localisation of type III, type IV and type VI secretion systems (T3SS, T4SS and T6SS, respectively) clusters in bacterial genomes.
Pedro Manuel Martínez-García +2 more
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Core architecture of a bacterial type II secretion system [PDF]
Nature Communications, 2018 SummaryBacterial type II secretion systems (T2SS) translocate virulence factors, toxins and enzymes across the cell outer membrane (OM). An assembled T2SS has not yet been isolated in vitro. Here we use a fusion of negative stain and cryo-electron microscopy (EM) to reveal the core architecture of an assembled T2SS from the pathogen Klebsiella ...
Chernyatina, Anastasia A, Low, Harry H
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Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system
Nature Communications, 2020 Bacterial Rhs proteins with toxic domains are often secreted by type VI secretion systems. Here, the authors show that one of these proteins self-cleaves into three fragments, with the Rhs core and the N-terminal domain facilitating secretion and ...
Tong-Tong Pei +11 more
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Communications BiologyType VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species ...
Wassim Daher +9 more
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The Haemophilus influenzae HMW1C protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin. [PDF]
PLoS Pathogens, 2010 The Haemophilus influenzae HMW1 adhesin is a high-molecular weight protein that is secreted by the bacterial two-partner secretion pathway and mediates adherence to respiratory epithelium, an essential early step in the pathogenesis of H.
Susan Grass +4 more
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