Results 61 to 70 of about 168,620 (156)

CryoEM of bacterial secretion systems: A primer for microbiologists

Molecular Microbiology, 2020
Abstract“CryoEM” has come of age, enabling considerable structural insights into many facets of molecular biology. Here, we present a primer for microbiologists to understand the capabilities and limitations of two complementary cryoEM techniques for studying bacterial secretion systems. The first, single particle analysis, determines the structures of
Trishant R. Umrekar, Eli Cohen, Tina Drobnič, Nayim Gonzalez‐Rodriguez, Morgan Beeby   +4 more
openaire   +2 more sources

The bacterial injection kit: Type III secretion systems

Annals of Medicine, 2005
Type III secretion (T3S) systems are widespread among Gram-negative bacteria pathogenic for animals and plants, including Yersinia spp., Salmonella spp., Shigella spp., enteropathogenic Escherichia coli, enterohaemorrhagic E. coli, or Pseudomonas spp.
Mota, L. J., Cornelis, G. R.
openaire   +3 more sources

Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase

mBio, 2016
Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole (BCV).
Erin P. Smith, Cheryl N. Miller, Robert Child, Jennifer A. Cundiff, Jean Celli   +4 more
doaj   +1 more source

Pantoea ananatis Genetic Diversity Analysis Reveals Limited Genomic Diversity as Well as Accessory Genes Correlated with Onion Pathogenicity

Frontiers in Microbiology, 2018
Pantoea ananatis is a member of the family Enterobacteriaceae and an enigmatic plant pathogen with a broad host range. Although P. ananatis strains can be aggressive on onion causing foliar necrosis and onion center rot, previous genomic analysis has ...
Shaun P. Stice, Spencer D. Stumpf, Ron D. Gitaitis, Brian H. Kvitko, Brian H. Kvitko, Bhabesh Dutta   +5 more
doaj   +1 more source

Structure of the Helicobacter pylori Cag type IV secretion system

eLife, 2019
Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells.
Jeong Min Chung, Michael J Sheedlo, Anne M Campbell, Neha Sawhney, Arwen E Frick-Cheng, Dana Borden Lacy, Timothy L Cover, Melanie D Ohi   +7 more
doaj   +1 more source

Bacterial secretion systems: Networks of pathogenic regulation and adaptation in mycobacteria and beyond. [PDF]

PLoS Pathog, 2022
Nicholson KR, Champion PA.
europepmc   +1 more source

Identification of a new export signal that targets early subunits to the flagellar type III secretion export machinery

mBio
Type III secretion systems (T3SSs) are essential for motility and virulence in many bacterial pathogens. Proteins destined for the flagellar T3SS contain at least two export signals in their N-terminal D0 domain.
Owain J. Bryant, Gillian M. Fraser
doaj   +1 more source

Bacterial type IV secretion system induces specific and nonspecific protective immunity

mBio
Pathogenic microbes trigger rapid and robust innate immune responses that effectively restrict pathogen replication and promote long-lasting adaptive immunity.
Fernanda V. S. Castanheira, Marcelo S. F. Pereira, Marco A. Ataide, Danielle P. A. Mascarenhas, Rhanoica O. Guerra, Gustavo F. S. Quirino, Fausto Almeida, Dario S. Zamboni   +7 more
doaj   +1 more source

Towards RNA delivery via bacterial secretion systems

, 2020
RNA is a versatile macromolecule with numerous therapeutic applications. However, delivering RNA and RNA:protein complexes efficiently into the appropriate cells and cellular compartments remains a significant challenge. As our ability to engineer bacteria has become more sophisticated, there has been increasing interest in utilising bacteria as ...
openaire   +3 more sources

Secretins of type-two secretion systems are necessary for exopolymeric slime secretion in cyanobacteria and myxobacteria

Nature Communications
Cyanobacteria and myxobacteria display gliding motility associated with the secretion of an exopolymeric slime through nozzle-like structures. Here, we use biochemical and structural assays to show that these nozzles are composed of secretins of the PilQ/
David M. Zuckerman, Jeffery Man To So, Egbert Hoiczyk   +2 more
doaj   +1 more source