Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Advancing Pediatric Antibacterial Drug Development: A Critical Need to Reinvent our Approach. [PDF]
, 2019 The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice.
Bradley, John +3 more
core +1 more source
Ethylene production in plants during transformation suppresses vir gene expression in Agrobacterium tumefaciens [PDF]
, 2008 •Ethylene evolution from plants inhibits Agrobacterium-mediated genetic transformation, but the mechanism is little understood. In this study, the possible role of ethylene in Agrobacterium-mediated genetic transformation was clarified.•It was tested ...
Ezura Hiroshi +6 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Development of an efficient transformation system for Dothistromin pini : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Genetics at Massey University [PDF]
, 1996 A transformation system has been developed for the plant pathogenic fungus Dothistroma pini using a positive selection system based on the Escherichia coli hygromycin B phosphotransferase gene (hph).
Bidlake, Anita Therese
core
Integrating functional diversity, food web processes, and biogeochemical carbon fluxes into a conceptual approach for modeling the upper ocean in a high-CO2 world [PDF]
, 2005 Marine food webs influence climate by channeling carbon below the permanent pycnocline, where it can be sequestered. Because most of the organic matter exported from the euphotic zone is remineralized within the "upper ocean" (i.e., the water column ...
Legendre, Louis, Rivkin, Richard B.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Factors affecting genetic transformation via Agrobacterium tumefaciens in Phaseolus vulgaris L.
Biotecnología Vegetal, 2013 Phaseolus genus, as well as other legumes, has proved recalcitrant plant regeneration in vitro and mainly to genetic transformation via Agrobacterium tumefaciens.
Amanda Martirena-Ramírez +1 more
doaj
Host-Mimicking Strategies in DNA Methylation for Improved Bacterial Transformation
, 2012 In 1928, Griffith [1] reported that soluble substances from virulent pneumococcal cells trans‐ formed non-virulent pneumococcus to virulent forms. This substance has now been demon‐ strated to be DNA [2-4].
Hirokazu Suzuki
semanticscholar +1 more source