Results 71 to 80 of about 109,795 (265)

PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS

Frontiers in Immunology, 2018
Although it is well-recognized that inflammation enhances leukocyte bactericidal activity, the underlying mechanisms are not clear. Here we report that PRL2 is sensitive to oxidative stress at inflamed sites.
Cennan Yin, Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu, Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo, Guangjie Chen, Zhaojun Wang   +11 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides.

PLoS ONE, 2015
All life forms are equipped with rapidly acting, evolutionally conserved components of an innate immune defense system that consists of a group of unique and diverse molecules known as host defense peptides (HDPs).
Parvin Abraham, Anand Sundaram, Asha R, Reshmy V, Sanil George, K Santhosh Kumar   +5 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

PEPTIDERGIC MECHANISMS OF REGULATION OF BACTERICIDAL ACTIVITY OF ALVEOLAR MACROPHAGES IN CONDITION OF EMOTIONAL STRESS

Acta Biomedica Scientifica, 2012
In present work the influence of chronic immobilization stress on bactericidal activity of alveolar macrophages after capsaicin application on the neck division of the right vagus nerve and intramuscular administration of leuenkephaline analog dalargine ...
I. G. Bryndina, N. N. Vasilyeva, M. V. Kazakova   +2 more
doaj  

Antibacterial Efficacy of Lytic Bacteriophages against Antibiotic-Resistant Klebsiella Species

The Scientific World Journal, 2011
Bacterial resistance to antibiotics is a leading and highly prevalent problem in the treatment of infectious diseases. Bacteriophages (phages) appear to be effective and safe alternatives for the treatment of resistant infections because of their ...
M. Khajeh Karamoddini, B. S. Fazli-Bazzaz, F. Emamipour, M. Sabouri Ghannad, A. R. Jahanshahi, N. Saed, A. Sahebkar   +6 more
doaj   +1 more source

BACTERICIDAL ACTIVITY OF LEUKOCYTES IN PULMONARY TUBERCULOSIS PATIENTS

Туберкулез и болезни лёгких, 2017
Bactericidal activity of leukocytes was investigated in 63 patients with new infiltrate pulmonary tuberculosis and 28 patients with fibrous cavernous pulmonary tuberculosis.
M. E. Dyakova, D. S. Esmedlyaeva, T. L. Perova, N. N. Petrischev, P. K. Yablonsky   +4 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Electric-field assisted growth and mechanical bactericidal performance of ZnO nanoarrays with gradient morphologies

Nanotechnology Reviews, 2019
In response to the widespread bacterial threat, mechanical bactericidal nanostructures with various morphologies have been reported for years. However, the relationship between morphology and bactericidal properties is still yet to be elucidated due to ...
Xie Yuan, Wei Wei, Meng Fanbin, Qu Xi, Li Jinyang, Wang Li, Zhou Zuowan   +6 more
doaj   +1 more source

Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide

AMB Express, 2017
N-chlorotaurine (NCT) and hydrogen peroxide are powerful endogenous antiseptics. In vivo, the reaction between hydrogen peroxide and metal ions leads to the formation of free hydroxyl radicals, which have an increased bactericidal activity.
Jasmin Mustedanagic, Valdecir Farias Ximenes, Markus Nagl   +2 more
doaj   +1 more source