Results 201 to 210 of about 296,685 (360)

NrdR in Streptococcus and Listeria spp.: DNA Helix Phase Dependence of the Bacterial Ribonucleotide Reductase Repressor

open access: yesMolecular Microbiology, Volume 123, Issue 5, Page 406-419, May 2025.
NrdR in Streptococcus and Listeria spp. regulates the expression of ribonucleotide reductase genes, which produce DNA building blocks. We show that NrdR binds DNA in an ATP/dATP‐dependent manner, and that optimal binding requires an integer number of DNA helix turns between NrdR boxes, with atypically long spacers in Streptococcus pneumoniae.
Saher Shahid   +5 more
wiley   +1 more source

The Human‐Specific miR‐6762‐5p Is an Activator of RhoA GTPase Enhancing Shigella flexneri Intercellular Spreading

open access: yesMolecular Microbiology, Volume 123, Issue 5, Page 420-432, May 2025.
Proposed model in which human miR‐6762‐5p expression activates RhoA to promote Shigella flexneri dissemination: During the late phase of infection, miR‐6762‐5p is expressed from its host gene TPCN1. This leads to RhoA activation and thus stress fiber formation.
Caroline Reisacher   +6 more
wiley   +1 more source

A Soluble Expression Construct of the Isolated Catalytic Domain of Plasmodium falciparum ATP4 Exhibits ATPase Activity Independent of a γ‐Phosphate Receiving Aspartate

open access: yesMolecular Microbiology, EarlyView.
Biochemical data on the isolated Na+/H+‐exchanging ATPase, PfATP4, from the malaria parasite are missing. Here, we expressed and purified the nucleotide and phosphate binding domains as a soluble protein and identified key residues by enzymatic characterization of generated point mutants.
Timo Beyer   +3 more
wiley   +1 more source

The Power Duo: How the Interplay Between Nucleoid‐Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony

open access: yesMolecular Microbiology, EarlyView.
Nucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Sara Moutacharrif   +6 more
wiley   +1 more source

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