Results 81 to 90 of about 190,483 (202)
Assembly and dynamics of the bacteriophage T4 homologous recombination machinery
Virology Journal, 2010 Homologous recombination (HR), a process involving the physical exchange of strands between homologous or nearly homologous DNA molecules, is critical for maintaining the genetic diversity and genome stability of species.
Morrical Scott W, Liu Jie
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Structure and Function of the T4 Spackle Protein Gp61.3
Viruses, 2020 The bacteriophage T4 genome contains two genes that code for proteins with lysozyme activity—e and 5. Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which is ...
Shuji Kanamaru +5 more
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Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers
Protein Science, Volume 35, Issue 9, September 2026.Abstract Alzheimer's disease affects tens of millions of people worldwide and is associated with the self‐assembly of the Aβ42 peptide into amyloid aggregates. Among the species formed during this process, soluble oligomeric intermediates are the most closely linked to neurotoxicity and are therefore an attractive target for both therapeutic and ...
Magdalena Nowinska +3 more
wiley +1 more source
Bacteriophages and their structural organisation [PDF]
, 2012 Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
E.V. Orlova, Orlova, Elena
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Sensors, 2009 Bacteriophage T4 nanoparticles possess characteristics that make them ideal candidates as materials for sensors, particularly as sensor probes. Their surface can be modified, either through genetic engineering or direct chemical conjugation to display ...
Jinny L. Liu, Marie J. Archer
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Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Structural morphing in a symmetry-mismatched viral vertex
Nature Communications, 2020 In icosahedral viruses, a symmetry-mismatched portal vertex is assembled by inserting a 12-fold-symmetric portal complex into a 5-fold-symmetric capsid environment.
Qianglin Fang +6 more
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Induced Dysbiosis Modifies Physiological Responses to Warming in a Temperate Sponge
Environmental Microbiology, Volume 28, Issue 9, September 2026.We investigated how microbiome disruption affects the physiological response of the calcareous sponge Rowella lancifera to simulated marine heatwave conditions. Antibiotic‐induced microbiome changes amplified physiological responses to increased temperatures, linking microbial stability to host performance.
Manon Broadribb +3 more
wiley +1 more source
Protein-Ligand Interactions: Docking, Design and Conformation Change [PDF]
, 2003 Virtual ligand screening has proven to be a successful strategy in drug design. An in house-developed procedure (HierDock), a coarse grain docking method followed by a fine grain search procedure, was used to determine the binding site for sugars in the
Datta, Deepshikha
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Synergistic engineering of Casδ nuclease for robust genome editing
Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3231-3242, September 2026.A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge +16 more
wiley +1 more source