Results 61 to 70 of about 47,591 (156)
Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems
Microbial Biotechnology, Volume 19, Issue 8, August 2026.Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 28, 24 July 2026.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Assembly and dynamics of the bacteriophage T4 homologous recombination machinery
Virology Journal, 2010 Homologous recombination (HR), a process involving the physical exchange of strands between homologous or nearly homologous DNA molecules, is critical for maintaining the genetic diversity and genome stability of species.
Morrical Scott W, Liu Jie
doaj +1 more source
Transcription activation by a sliding clamp
Nature Communications, 2021 Transcription activation of late genes in T4 bacteriophage requires the promoter specificity factor gp55, the coactivator gp33 and the sliding clamp gp45.
Jing Shi +5 more
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DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, Volume 13, Issue 37, 3 July 2026.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
Genetic diversity among five T4-like bacteriophages
Virology Journal, 2006 Background Bacteriophages are an important repository of genetic diversity. As one of the major constituents of terrestrial biomass, they exert profound effects on the earth's ecology and microbial evolution by mediating horizontal gene transfer between ...
Bertrand Claire +4 more
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Structure and Function of the T4 Spackle Protein Gp61.3
Viruses, 2020 The bacteriophage T4 genome contains two genes that code for proteins with lysozyme activity—e and 5. Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which is ...
Shuji Kanamaru +5 more
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Engineered B7‐H3 Binding in Modular Gp2 Miniproteins
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1871-1881, July 2026.ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn +5 more
wiley +1 more source
Sensors, 2009 Bacteriophage T4 nanoparticles possess characteristics that make them ideal candidates as materials for sensors, particularly as sensor probes. Their surface can be modified, either through genetic engineering or direct chemical conjugation to display ...
Jinny L. Liu, Marie J. Archer
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Current Protocols, Volume 6, Issue 7, July 2026.Abstract Nanobodies are small but specific heavy chain–only antibody fragments. Their small size, relative stability, and ability to access difficult to reach deep‐tissue antigens makes them valuable research, diagnostic, and therapeutic tools. Nanobodies are derived from the variable heavy (VH) domain of heavy chain–only antibodies that are unique to ...
Tessa J. Casselman +6 more
wiley +1 more source