Results 61 to 70 of about 190,483 (202)

T4 phage and its head surface proteins do not stimulate inflammatory mediator production. [PDF]

PLoS ONE, 2013
Viruses are potent activators of the signal pathways leading to increased cytokine or ROS production. The effects exerted on the immune system are usually mediated by viral proteins. Complementary to the progress in phage therapy practice, advancement of
Paulina Miernikiewicz, Krystyna Dąbrowska, Agnieszka Piotrowicz, Barbara Owczarek, Justyna Wojas-Turek, Jagoda Kicielińska, Joanna Rossowska, Elżbieta Pajtasz-Piasecka, Katarzyna Hodyra, Katarzyna Macegoniuk, Kamila Rzewucka, Agnieszka Kopciuch, Tomasz Majka, Andrey Letarov, Eugene Kulikov, Henryk Maciejewski, Andrzej Górski   +16 more
doaj   +1 more source

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley   +1 more source

A viral genome packaging ring-ATPase is a flexibly coordinated pentamer

Nature Communications, 2021
In viruses, multi-subunit ring-ATPases are involved in genome packaging. Here, using single-molecule techniques, the authors determine that the active bacteriophage T4 DNA packaging motor is a pentamer and show that the motor can tolerate inactive ...
Li Dai, Digvijay Singh, Suoang Lu, Vishal I. Kottadiel, Reza Vafabakhsh, Marthandan Mahalingam, Yann R. Chemla, Taekjip Ha, Venigalla B. Rao   +8 more
doaj   +1 more source

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak, Michelle C. M. van Winden, Thomas V. Harwood, Rachel Neurath, Suzanne M. Kosina, Katherine B. Louie, Matthew B. Sullivan, Simon Roux, Karsten Zengler, Vivek K. Mutalik, Trent R. Northen   +10 more
wiley   +1 more source

Analysis of inhibitors of bacteriophage T4 DNA polymerase

, 1994
Bacteriophage T4 DNA polymerase was Inhibited by butylphenyl nucleotldes, aphldlcolin and pyrophosphate analogs, but with lower sensitivities than other members of the B family DNA polymerases.
Reha-Krantz, L.J., Khan, N.N., Wright, G.E.   +2 more
core   +1 more source

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein [PDF]

, 1990
Maillou J, Dreiseikelmann B. The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein. Virology. 1990;175(2):500-507.The sim gene of bacteriophage P1 causes exclusion of a superinfecting P1 phage.
Maillou, Julia, Dreiseikelmann, Brigitte
core   +1 more source

The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration

BMC Microbiology, 2009
Background The antibacterial activity of bacteriophages has been described rather well. However, knowledge about the direct interactions of bacteriophages with mammalian organisms and their other, i.e.
Boratyński Janusz, Świtała-Jeleń Kinga, Żaczek Maciej, Owczarek Barbara, Wietrzyk Joanna, Kurzępa Aneta, Jończyk Paulina, Skaradziński Grzegorz, Dąbrowska Krystyna, Poźniak Gryzelda, Maciejewska Magdalena, Górski Andrzej   +11 more
doaj   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Transcription of the T4 late genes

Virology Journal, 2010
This article reviews the current state of understanding of the regulated transcription of the bacteriophage T4 late genes, with a focus on the underlying biochemical mechanisms, which turn out to be unique to the T4-related family of phages or ...
Kassavetis George A, Geiduschek E Peter
doaj   +1 more source