Results 81 to 90 of about 11,802,102 (404)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

New Brucella variant isolated from Croatian cattle

BMC Veterinary Research, 2021
Background A novel Brucella strain closely related to Brucella (B.) melitensis biovar (bv) 3 was found in Croatian cattle during testing within a brucellosis eradication programme.
Silvio Spicic, Maja Zdelar-Tuk, Claire Ponsart, Rene S. Hendriksen, Irena Reil, Guillaume Girault, Pimlapas Leekitcharoenphon, Vesna Rukavina, Martina Rubin, Luca Freddi, Sanja Duvnjak   +10 more
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

ORIGINAL ARTICLE: Multidrug Resistance and Phage Pattern of Staphylococcus aureus in Pyoderma Cases [PDF]

Journal of Krishna Institute of Medical Sciences University, 2012
Background: Pyoderma is common in India and other tropical countries. Staphylococcus aureus is the commonest causative agent ofpyoderma. Aims and Objectives: To know the antibiotic susceptibility and bacteriophage pattern of Staphylococcus aureus ...
Sanjay M. Wavare, Sarita N. Kothadia, Mangala P. Ghatole   +2 more
doaj  

Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt

mSphere, 2021
Infection by multidrug-resistant (MDR) Acinetobacter baumannii is one of the major causes of hospital-acquired infections worldwide. The ability of A. baumannii to survive in adverse conditions as well as its extensive antimicrobial resistance make it ...
Deena Jalal, Mariam G. Elzayat, Aya A. Diab, Hend E. El-Shqanqery, Omar Samir, Usama Bakry, Reem Hassan, Mervat Elanany, Lobna Shalaby, Ahmed A. Sayed   +9 more
doaj   +1 more source

A Single-Molecule Hershey-Chase Experiment [PDF]

Current Biology (2012), Volume 22, Issue 14, 1339-1343, 2012
Ever since Hershey and Chase used phages to establish DNA as the carrier of genetic information in 1952, the precise mechanisms of phage DNA translocation have been a mystery. While bulk measurements have set a time scale for in vivo DNA translocation during bacteriophage infection, measurements of DNA ejection by single bacteriophages have only been ...
arxiv   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

The Typing of Salmonella thompson by Means of Bacteriophage [PDF]

Journal of General Microbiology, 1951
SUMMARY: By the use of seven phage preparations, forty-one of fifty smooth strains of Salmonella thompson were classified into eleven types. The remaining nine strains were insusceptible to all the test phages; mouse passage did not render them susceptible.
openaire   +3 more sources

DNA homology within the Rhizobiaceae : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University [PDF]

, 1984
The relationship of rhizobia that nodulate Galega officinalis to the known species of Rhizobium and Bradyrhizobium was investigated. Similarly, the recently discovered fast­ growing soybean nodulating group of rhizobia was studied. Both groups were
Wedlock, David Neil
core  

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source