Results 121 to 130 of about 7,354 (190)

2′-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1

International Journal of Molecular Sciences
2′-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of Cinnamomum cassia, has anti-inflammatory and anti-tumor activities. In this study, we explored whether HCA preconditioning could protect the heart against ischemia/reperfusion (I/
Yu-Hsuan Cheng, Chih-Yao Chiang, Chung-Hsin Wu, Chiang-Ting Chien   +3 more
semanticscholar   +1 more source

The Role of BAG3 Protein Interactions in Cardiomyopathies

Bcl-2-associated athanogene 3 (BAG3) plays an important function in cellular protein quality control (PQC) maintaining proteome stability. Mutations in the BAG3 gene result in cardiomyopathies.
Ju-Fang Wang, Alexandre Rosa-Campos, Arthur M. Feldman, Hui-Qi Qu, Hakon Hakonarson   +4 more
core   +1 more source

Overexpression of BAG3 (Bcl2-associated athanogene 3) in serum and skin of patients with systemic sclerosis.

Clinical and Experimental Rheumatology
OBJECTIVES BAG3 (Bcl2-associated athanogene3) is able to induce the transformation of cancer-associated fibroblasts to alpha smooth muscle actin (a-SMA) positive (+) myofibroblasts.
Margot De Marco, G. Armentaro, A. Falco, A. Minniti, A. Cammarota, Claudia Iannone, A. Basile, A. D'Ardia, P. Zeppa, L. Marzullo, Alessandra Rosati, Claudio Vitali, R. Caporali, N. Del Papa   +13 more
semanticscholar   +1 more source

Evidence for BAG3 modulation of HIV-1 gene transcription. [PDF]

, 2007
A family of co-chaperone proteins that share the Bcl-2-associated athanogene (BAG) domain are involved in a number of cellular processes, including proliferation and apoptosis.
ROSATI, ALESSANDRA, TURCO, Maria Caterina, DEL VALLE L, KHALILI K, AMINI S, LEONE A   +5 more
core  

Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy

Disease Models & Mechanisms, 2023
Yonghe Ding, Mingmin Wang, Haisong Bu, Jiarong Li, Xueying Lin, Xiaolei Xu   +5 more
doaj   +1 more source

Functional Characterization of Interaction Partners of the Co-Chaperone BAG3 [PDF]

, 2018
Protein homeostasis (proteostasis) describes the cellular balance between protein synthesis, function and degradation. The stress inducible co-chaperone BAG3 is a key factor in proteostasis, in particular under mechanical stress.
Zeidler, Claudia
core  

P209L Mutation in BAG3 Does Not Cause Cardiomyopathy in Mice [PDF]

, 2018
Cardiomyocytes are under constant mechanical and metabolic stress, which makes functional protein quality control (PQC) systems particularly important. Molecular chaperones and co-chaperones are essential components of a functioning PQC.
Zhou, Paul
core  

Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes. [PDF]

Mater Today Bio
Wang C, Mai NY, Donelson FJ, Moradi Nasab S, Shi H, Yang H, Mather PT, Wang X, Henderson JH, Ma Z.   +9 more
europepmc   +1 more source

Bioinformatics Screening and Preliminary Experimental Verification of Integrated Stress Response-Associated MYC and BAG3 in Chronic Obstructive Pulmonary Disease. [PDF]

Int J Chron Obstruct Pulmon Dis
Liu X, Wang L, Tang T, Qian H, He B, Xu Z, Wang G, Zhang M.   +7 more
europepmc   +1 more source

Antibodies anti-Bag3 as biochemical serum and tissue marker

, 2012
The present disclosure concerns the field of diagnostic biological markers. Specifically the disclosure relates to anti-BAG3 antibodies for use as biological markers for the diagnosis of a pathological state. Furthermore, the disclosure involves specific
TURCO, Maria Caterina
core