Results 111 to 120 of about 7,354 (190)

BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922

Past studies have shown that mutant KRAS colon cancer cells are susceptible to apoptosis induced by the HSP90 inhibitor AUY922. Nevertheless, intrinsic and acquired resistance remains an obstacle for the potential application of the inhibitor in the ...
Lei Jin (21132170), Chun Yan Wang (14919945), Chen Chen Jiang (21131984), Xu Dong Zhang (21134519), Su Tang Guo (14919942), Xu Yan (21134753), Amanda Croft (21138647)   +6 more
core  

miR-129-1-3p down-regulation promotes BAG cochaperone 3 (BAG3)-driven pro-fibrotic processes in primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa

Non-coding RNA Research
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and severe skin fragility disease due to loss-of-function mutations in the COL7A1 gene.
R. Nobili, C. Barbagallo, M. Ragusa, J. Genovese, V. D’Agostino, A. Diociaiuti, Daniele Castiglia, T. Odorisio, Giovanna Zambruno, M. El Hachem, A. Condorelli   +10 more
semanticscholar   +1 more source

BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling

Cardiovascular Diabetology
Diabetic vascular remodeling is the most important pathological basis of diabetic cardiovascular complications. The accumulation of advanced glycation end products (AGEs) caused by elevated blood glucose promotes the proliferation and migration of ...
Xin-Yue Huang, Jia-Yan Guo, An-Qi Ning, Nai-Jin Zhang, Ying-Fen Sun   +4 more
semanticscholar   +1 more source

O‐GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co‐chaperone

Protein Science
Almost all types of cellular stress induce post‐translational O‐GlcNAc modifications of proteins, and this increase promotes cell survival. We previously demonstrated that O‐GlcNAc on certain small heat shock proteins (sHSPs), including HSP27, directly ...
Afraah Javed, O. T. Johnson, Aaron T. Balana, Regan F. Volk, Andreas Langen, Benjamin S Ahn, Balyn W. Zaro, J. Gestwicki, Matthew R. Pratt   +8 more
semanticscholar   +1 more source

BAG3 protein delocalisation in prostate carcinoma.

, 2010
Despite the progressive increase of early diagnosis, a subset of prostate cancers show a metastasizing and lethal course, not always predictable upon the traditional prognostic parameters.
Di Benedetto M., Mascolo M, Staibano S, Di Benedetto M, Morena A, Rocco A., Salerno V, TURCO, Maria Caterina, Salerno V., Morena A., Morelli E., Vecchione ML, Di Lorenzo G., AUTORINO, Riccardo, Turco M. C., Autorino R., Mascolo M., Ilardi G, Staibano S., Turco MC, Autorino R, Ilardi G., Rocco A, Vecchione M. L., Di Lorenzo G   +24 more
core   +1 more source

DEMYSTIFYING BAG3 CARDIOMYOPATHY

American Journal of Preventive Cardiology
Therapeutic Area: Heart Failure Case Presentation: A 56-year-old male with progressive exertional dyspnea and ankle edema was evaluated in the cardiology office. The patient had no overt traditional cardiac risk factors.
Yulith Roca Alvarez, MD
doaj   +1 more source

Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic.

Current Biology
Proteome maintenance in contracting skeletal and cardiac muscles depends on the chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and heart failure in animal models and patients.
Judith Ottensmeyer, Alessandra Esch, Henrique Baeta, Sandro Sieger, Yamini Gupta, Maximilian F. Rathmann, Andreas Jeschke, D. Jacko, Kirill Schaaf, Thorsten Schiffer, B. Rahimi, Lukas Lövenich, A. Sisto, P. F. M. van der Ven, D. Fürst, Albert Haas, Wilhelm Bloch, S. Gehlert, Bernd Hoffmann, Vincent Timmerman, P. Huesgen, J. Höhfeld   +21 more
semanticscholar   +1 more source

BAG3 sequesters VP40 away from the plasma membrane.

, 2017
HEK293T cells were mock-transfected or transfected with eVP40 (A) or mVP40 (C) plus either BAG3-WT, or BAG3-ΔN as indicated. Cytosol and plasma membrane (PM) fractions were isolated at 24 hrs post-transfection, and the indicated proteins were detected by
Jingjing Liang (413293), Ronald N. Harty (819814), Mark T. Bedford (182601), Sachdev S. Sidhu (141559), Marius Sudol (590085), Ziying Han (347945), Cari A. Sagum (3631066)   +6 more
core   +1 more source

Characterization of the myopathy associated BAG3 P209L mutation

, 2013
Myofibrillar myopathy is a protein aggregate myopathy characterized by disintegration of the Z-disk and accumulation of protein aggregates. A dominant missense mutation (P209L) in the co-chaperone BAG3 has been associated with a severe early onset form ...
CARRA, Serena, Kampinga, Harm H., Meister, Melanie, Minoia, Melania, Kanon, Bart   +4 more
core  

Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3

JAMA cardiology
IMPORTANCE The genetic factors that modulate the reduced penetrance and variable expressivity of heritable dilated cardiomyopathy (DCM) are largely unknown.
J. Park, M. Levin, David Y. Zhang, N. Reza, Jonathan O. Mead, Eric D. Carruth, Melissa A. Kelly, Alexandra Winters, Colleen M. Kripke, R. Judy, S. Damrauer, Anjali T. Owens, L. Bastarache, A. Verma, D. Kinnamon, R. E. Hershberger, M. Ritchie, Daniel J. Rader   +17 more
semanticscholar   +1 more source