Results 91 to 100 of about 7,354 (190)

BAG3 is involved in neuronal differentiation and migration [PDF]

, 2017
Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with several heat shock proteins. It plays a key role in protein quality control and mediates the clearance of misfolded proteins.
Vanessa Nicolin, SANTORO, Antonietta, Florenzano, Fulvio, Alessandra Rosati, Stefania L. Nori, Mario Capunzo, Nicolin, Vanessa, CAPUNZO, Mario, ROSATI, Alessandra, Antonietta Santoro, NORI, Stefania Lucia, Fulvio Florenzano, Nori, Stefania L.   +12 more
core   +2 more sources

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, Volume 2, Issue 3, September 2026.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, Volume 4, Issue 3, Page 262-274, September 2026.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation

Cancer Biology & Therapy
The incidence of intrahepatic cholangiocarcinoma (ICC) is steadily rising, and it is associated with a high mortality rate. Clinical samples were collected to detect the expression of HSPB8 and BAG3 in ICC tissues. ICC cells were cultured and transfected
Bo Shu, Yu Wen, Ronghua Lin, Chao He, Cailan Luo, Fazhao Li   +5 more
doaj   +1 more source

Dilated Cardiomyopathy: A Novel BAG3 Mutation Associated with Aggressive Disease Progression and Ventricular Arrhythmias

Journal of Cardiovascular Development and Disease
We present the case of a 46-year-old man with a history of complex ventricular arrhythmias preceding the development of asymptomatic mild left ventricular dysfunction, who presented with acute-onset heart failure and was ultimately diagnosed with dilated
P. Pastori, Cristina Balla, Marta Rasia, Emilia Lo Jacono, Clelia Guerra, Roberta Schininà, F. Gualandi, Matteo Bertini, G. Tortorella   +8 more
semanticscholar   +1 more source

The prosurvival protein BAG3: a new participant in vascular homeostasis

, 2017
Bcl2-associated athanogene 3 (BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors.
Damato, Antonio, Carrizzo, Albino, Falco, Antonia, Capunzo, Mario, Rosati, Alessandra, Januzzi, James, Ambrosio, Mariateresa, Madonna, Michele, Turco, Maria C, De Laurenzi, Vincenzo, Vecchione, Carmine   +10 more
core   +1 more source

Fragment-based discovery of novel small molecule targeting human BAG3

European Journal of Medicinal Chemistry Reports
Bcl-2-associated athanogene 3 (BAG3) is a multifunctional co-chaperone protein that regulates apoptosis, autophagy, and proteostasis through interactions with HSP70 and other partners. Overexpression of BAG3 contributes to tumor cell survival, metastasis,
Annagiulia Favaro, Chiara Marchioro, Martina Canton, Thomas Stella, Romeo Romagnoli, Elena Mariotto, Mattia Sturlese, Giampietro Viola   +7 more
doaj   +1 more source

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks [PDF]

, 2014
Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling.
Rauch, Jennifer N, Gabai, Vladimir L, Li, Xiaokai, Gong, Jianlin, Smirnova, Svetlana G, Gestwicki, Jason E, Matchuk, Olga N, Calderwood, Stuart K, Li, Hu, Gummuluru, Suryaram, Zamulaeva, Irina A, Orlova, Nina V, Takayama, Shinichi, Colvin, Teresa A, Sherman, Michael Y, Garcia-Marcos, Mikel, Young, ZT   +16 more
core   +1 more source

DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus

Microbiome
Oral lichen planus (OLP) is one of the most frequent oral mucosal diseases associated with chronic inflammation, despite a profoundly limited understanding of its underlying pathogenic mechanisms.
Xiaoli Ji, Meng-Fan Zhi, Xiufeng Gu, Ying Han, Xiang Lan, Li-Xiang Song, Peipei Sun, Jingyuan Li, Xiang-Min Qi, Qiang Feng   +9 more
semanticscholar   +1 more source