Results 71 to 80 of about 7,354 (190)

Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep

Integrative Zoology, EarlyView.
SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu, Xue Li, Fei Tian, Xuexia Li, Wenxia Li, Buying Han, Ming Jiang, Yanlan Liu, Xiliu Hu, Xue Xiang, Wulong Ma, Guangcai Bao, Rong Li, Guoxiang Bao, Sijia Liu, Kai Zhao, Dehong Tian   +16 more
wiley   +1 more source

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. [PDF]

, 2017
Molecular chaperones regulate quality control in the human proteome, pathways that have been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure ...
Jennie C. Yoo, Yoo, Jennie C, Po-Lin So, Mandegar, Mohammad, Conklin, Bruce, Pruitt, Beth, Mandegar, Mohammad A, Bruce R. Conklin, Ribeiro, Alexandre Js, Judge, Luke M, So, Po-Lin, Srivastava, Deepak, Mohammad A. Mandegar, Robyn M. Kaake, Kaake, Robyn M, Krogan, Nevan, Pruitt, Beth L, Alexandre J.S. Ribeiro, Christina L. Jensen, Conklin, Bruce R, Annie Truong, Jensen, Christina L, Luke M. Judge, Nevan J. Krogan, Ribeiro, Alexandre, Perez-Bermejo, Juan, Beth L. Pruitt, Yoo, Jennie, Huebsch, Nathaniel, Truong, Annie, Deepak Srivastava, Krogan, Nevan J, Jensen, Christina, Perez-Bermejo, Juan A, Juan A. Perez-Bermejo, Judge, Luke, Nathaniel Huebsch, Kaake, Robyn   +37 more
core   +1 more source

Ruolo della proteina BAG3 nel microambiente tumorale [PDF]

, 2012
2009 - 2010Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro.
Falco, Antonia
core   +1 more source

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

PLoS Genetics, 2015
The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in protein quality control during mechanical strain. It is part of a multichaperone complex that senses damaged cytoskeletal proteins and orchestrates their seclusion and ...
Margit Fuchs, Carole Luthold, Solenn M Guilbert, Alice Anaïs Varlet, Herman Lambert, Alexandra Jetté, Sabine Elowe, Jacques Landry, Josée N Lavoie   +8 more
doaj   +1 more source

BAG3 recognizes folding status of αB-crystallin.

, 2013
(A) BAG3 binds to mutant type of αB-crystallin strongly. Wild type (WT) or mutant (R120G) αB-crystallin was expressed in HEK293 cells with Flag-tagged BAG3, and the cell lysate was mixed with anti-Flag antibody.
Shinichi Takayama (354627), Akinori Hishiya (354624), Serena Carra (354626), Harm H. Kampinga (82770), Mortada Najem Salman (354625)   +4 more
core   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease-linked proteins via proteasome, autophagy, and retromer complex interactions

bioRxiv
Background Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone assisted selective autophagy, and in the brain, most highly expressed in astrocytes. However, its role in astrocytes remains poorly defined.
Zachary M. Augur, Garrett M. Fogo, Courtney R. Benoit, Gizem Terzioglu, Z. R. Murphy, Mason R. Arbery, Natacha Comandante-Lou, D. Duong, N. Seyfried, P. D. De Jager, Tracy L. Young-Pearse   +10 more
semanticscholar   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates

European Journal of Medical Research
Purpose BCL-2-associated athanogene 3 (BAG3) is an anti-apoptotic protein that plays an essential role in the onset and progression of multiple cancer types.
Binghao Gong, Yuan Huang, Zhenting Wang, Bangbei Wan, Yaohui Zeng, Cai Lv   +5 more
doaj   +1 more source

USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway

Oncogenesis
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear.
Shuang Li, Li-Na Yang, Xiao-Yan Ding, Hongxiao Sun, Xiaolei Dong, Fanghao Yang, Mengjun Wang, Hu-Hu Zhang, Ya Li, Bing Li, Chun-Yan Liu   +10 more
semanticscholar   +1 more source