Results 51 to 60 of about 7,354 (190)
AutophagyTargeting mutant (MUT) TP53 is crucial in anticancer therapy, given the oncogenic properties that these proteins often acquire. Therefore, it is of paramount importance to unravel strategies and mechanisms through which this goal can be achieved ...
Michele Di Crosta +7 more
semanticscholar +1 more source
, 2017 (A) GST Pull-Down showing interaction of GFP-BAG3 expressed in HEK293 cells and recombinant GST-HSPB7. GFP-BAG3 was expressed in HEK293 cells (cell extract panel) and and GST-HSPB7 was produced in a bacterial expression system. GST-HSPB7 co-sediment with
Declan P. O'Regan (3838759) +34 more
core +1 more source
Effect of Bcl-2-associated athanogene 3 on the proliferation and migration of non-small cell lung cancer cells [PDF]
精准医学杂志Objective To investigate the effect of Bcl-2-associated athanogene 3 (BAG3) on the proliferation and migration abilities of non-small cell lung cancer (NSCLC) cells.
LI Shuang, SONG Xinying, LIU Chunyan, LI Bing
doaj +1 more source
iScience, 2022 Summary: The major heat shock protein Hsp70 forms a complex with a scaffold protein Bag3 that links it to components of signaling pathways. Via these interactions, the Hsp70-Bag3 module functions as a proteotoxicity sensor that controls cell signaling ...
Shivani Patel +5 more
doaj +1 more source
Science Advancesβ-Site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for amyloid-β (Aβ) generation and is considered promising drug target for Alzheimer’s disease (AD).
Lei Xia +14 more
semanticscholar +1 more source
Regulation des Cochaperons BAG3 durch Phosphorylierung und Dephosphorylierung [PDF]
, 2020 Die Zelle ist die kleinste Organisationseinheit, aus der alle Organismen aufgebaut sind. Sie ist auf ein Gleichgewicht der Proteinausstattung, die Proteostase, angewiesen.
Wördehoff, Judith Friederike
core +1 more source
BAG3++: An Extensible Generator Framework for Automated Layout-Aware AMS Design
IEEE Open Journal of Circuits and SystemsWe present BAG $3{++}$ , an extensible analog/mixed-signal (AMS) design framework for layout-aware design. BAG $3{++}$ realizes a unified design environment that merges schematic, layout, and verification views into a single development interface.
Felicia B. Guo +7 more
semanticscholar +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source
Acta NeuropathologicaGrowing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheimer’s disease (AD) and AD-related dementia (ADRD). Nevertheless, the molecular mechanisms underlying TBI-induced AD-like pathology and
Nicholas Sweeney +23 more
semanticscholar +1 more source
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source