Results 31 to 40 of about 7,354 (190)
Characterization of the Full-Length BAG3 Protein and Stress Induced Formation of BAG3-Z [PDF]
, 2023 Bcl2-associated athanogene-3 (BAG3) is a pro-autophagy co-chaperone that we havepreviously shown localizes to the cardiac sarcomere and is critical for proteostasis and maintenance of normal sarcomeric function.
Zied, Ahmed Gamal Abdalla
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BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity. [PDF]
PLoS ONE, 2011 A homozygous disruption or genetic mutation of the bag3 gene causes progressive myofibrillar myopathy in mouse and human skeletal and cardiac muscle disorder while mutations in the small heat shock protein αB-crystallin gene (CRYAB) are reported to be ...
Akinori Hishiya +4 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2021 Notwithstanding previous studies have proved the anti-apoptotic effect of Bcl-2 associated athanogene3 (BAG3) in myocardium, the structural domains PXXP and BAG responsible for its protection are not reformed. Since BAG3 in cardiomyocytes is a new target
Ling-Ling Zhao +10 more
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BMC Cancer, 2018 Background CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors.
Ning Li +7 more
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Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency.
PLoS Genetics, 2020 Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM), resulting in systolic dysfunction and heart failure, as well as myofibrillar myopathy (MFM), which is characterized by protein ...
Federica Diofano +5 more
doaj +1 more source
Cells, 2020 BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis.
Donat Kögel +4 more
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Clinical and Translational Medicine, 2022 Background Exaggerated fibroblast proliferation is a well‐known feature in idiopathic pulmonary fibrosis (IPF) which may be – in part – due to insufficient autophagy, a lysosome dependent cellular surveillance pathway. Bcl2‐associated athanogene 3 (BAG3)
Shashipavan Chillappagari +10 more
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BAG3 (Bcl-2 associated athanogene 3) [PDF]
, 2014 Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain.
Turco, MC +3 more
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Journal of Obstetrics and Gynaecology, 2023 BAG3 is a co-chaperone BAG family protein that plays important roles in protein homeostasis, cell survival, cell motility, and tumour metastasis. This study aimed to clarify the clinicopathological and prognostic implications of BAG3 mRNA expression in ...
Zi-mo Wang +4 more
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BAG3 role in cardiomyocytes physiopathology [PDF]
, 2013 2010 - 2011The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful stimuli.
De Marco, Margot
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