Results 11 to 20 of about 7,354 (190)

Knockdown of CREB3L4 Inhibits Autophagy and Reduces Cisplatin Resistance in Gastric Cancer Cells by Downregulating BAG3 [PDF]

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cisplatin resistance remains a major obstacle in the treatment of gastric cancer (GC), and autophagy has been increasingly recognized as a key cytoprotective mechanism contributing to chemoresistance. CREB3L4 is an endoplasmic reticulum membrane‐bound transcription factor that has been shown to regulate the expression of Bcl‐2 associated ...
Wen‐Ke Yin, Xue‐Mei Xie, Xiao‐Yan Song, Yue Xiang   +3 more
wiley   +2 more sources

BAG3+ CAF-T cell neighborhood predicts resistance to neoadjuvant chemoimmunotherapy in NSCLC [PDF]

Frontiers in Immunology
BackgroundDespite significantly improving outcomes in non-small cell lung cancer (NSCLC), neoadjuvant chemoimmunotherapy (NCIT) fails to achieve a major pathological response (MPR) in over 40% of patients.
Jing Sun, Zhengqi Cao, Yueping Jin, Anni Wang, Li Lu, Lixuan Chen, Wenhui Shi, Peiyi Xu, Yuxin Ouyang, Junjie Tang, Zhouwenli Meng, Ziming Li   +11 more
doaj   +2 more sources

Identification of phosphatases that dephosphorylate the co-chaperone BAG3

Life Science Alliance
PP1 catalyses the dephosphorylation at BAG3-pS136, inhibiting its association with 14-3-3 proteins. PP5 targets a BAG3 phosphorylation-site cluster, including pT285, regulating the interaction of BAG3 with HspB8 as well as BAG3-mediated protein ...
Thomas Kokot, Johannes P Zimmermann, Yamini Chand, Fabrice Krier, Lena Reimann, Laura Scheinost, Nico Höfflin, Alessandra Esch, Jörg Höhfeld, Bettina Warscheid, Maja Köhn   +10 more
doaj   +2 more sources

The Multifunctional Protein BAG3

JACC: Basic to Translational Science, 2018
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer.
Valerie D. Myers, MS, Joseph M. McClung, PhD, JuFang Wang, MD, Farzaneh G. Tahrir, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Christopher H. Kontos, MD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD   +9 more
doaj   +2 more sources

A novel duplication frameshift mutation in the BAG3 gene in a patient with dilated cardiomyopathy [PDF]

BMC Cardiovascular Disorders
Background/Objectives Dilated cardiomyopathy (DCM) is characterized by heart failure and cardiac dilation, distinguishing it from ischemic and non-ischemic heart diseases.
Wei Zhang, Kaihang Xu, Shiguang Liu, Juan Chen, Hua Jiang   +4 more
doaj   +2 more sources

Disease spectrum and long-term prognosis of patients with BAG3-associated neuromuscular diseases in Europe [PDF]

Brain
De novo or autosomal dominant BAG3 gene variants cause a wide range of skeletal and cardiac muscle diseases encompassing Charcot–Marie–Tooth disease, myofibrillar myopathy, cardiomyopathy or a combination of them.
G. Fernández-Eulate, C. Gitiaux, Simone Thiele, H. Jungbluth, A. Potulska-Chromik, C. Marini-Bettolo, J. Davion, G. Morís, E. Gallardo, M. Olivé, C. P. D. Fuenmayor-Fernández de la Hoz, F. Audic, Arnaud Isapof, Maggie C. Walter, Corrado Angelini, E. Bertini, U. Schara-Schmidt, K. Claeys, M. Dohrn, Mohamed Dembélé, F. Fer, G. Brochier, T. Evangelista, A. Kostera-Pruszczyk, S. Attarian, V. Straub, C. Domínguez-gonzález, J. Vissing, P. Richard, C. Métay, D. Khraiche, K. Wahbi, T. Stojkovic   +32 more
semanticscholar   +2 more sources

Identifying regulatory muscle processes in infantile and adult Pompe patients using a multi‐omic and morphological approach [PDF]

Brain Pathology, EarlyView.
The study highlights differences in the regulatory processes of skeletal muscle, such as sarcomeric contractility, lysosomal and autophagic function, metabolic activity and immune regulation, at transcriptomic and proteomic levels in infantile and adult Pompe disease.
Alexander Schaiter, Keerthika Lohanadan, Alexander Mensch, Andreas Hentschel, Angela Rosenbohm, Cornelia Kornblum, Angela Roth, Tara Procida‐Kowalski, Heidrun H. Krämer, Andreas Hahn, Jörg Höhfeld, Dieter O. Fürst, Werner Stenzel, Peter F. M. van der Ven, Andreas Roos, Marek Bartkuhn, Anne Schänzer   +16 more
wiley   +2 more sources

BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes [PDF]

Am J Physiol Cell Physiol
In a healthy brain, astrocytes maintain neuronal homeostasis by removing proteins like tau from the extracellular space, preventing their uptake by neurons. In Alzheimer’s disease (AD), this function is impaired, contributing to tau accumulation. Many AD
Joel Rodwell-Bullock, Ella Blau, Archan Ganguly, Carol Deaton, G. V. Johnson   +4 more
semanticscholar   +2 more sources

Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis [PDF]

Acta Neuropathol
The autophagy–lysosome pathway (ALP) and the ubiquitin–proteasome system (UPS) are the primary protein degradative mechanisms maintaining proteostasis in neurons.
Zachary M. Augur, Garrett M. Fogo, Mason R. Arbery, Yi-Chen Hsieh, Nalini R. Rao, Kritika Goyal, Emily X Dexter, David A. Bennett, Jeffrey N. Savas, Andrew M. Stern, Tracy L. Young-Pearse   +10 more
semanticscholar   +2 more sources

Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction.

JACC Basic To Translational Science, 2016
Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001 ...
Kamel Khalili, MANISH Gupta
exaly   +3 more sources