Results 1 to 10 of about 1,574 (125)
Redox Biology, 2022 Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. Bcl-2-associated athanogene 3 (BAG3) is a molecular chaperone regulator of
Liu Cao, Jingwei Liu, Yingxian Sun
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BAG3 Proteomic Signature under Proteostasis Stress
Cells, 2020 The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network.
Christian Behl +2 more
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Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy
The Journal of Clinical InvestigationLoss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function of BAG3 in other cardiac cell types is understudied. In this study, we used an
Bryan Z. Wang +23 more
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An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
Neuron, 2023 SUMMARY The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology are unknown. Here, we show that global post-natal deletion of Bmal1 in
Erik Musiek
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Development of an anti-BAG3 humanized antibody for treatment of pancreatic cancer
Molecular Oncology, 2019 We have previously shown that secreted BAG3 is a potential target for the treatment of pancreatic ductal adenocarcinoma and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti‐BAG3 murine antibody.
Liberato Marzullo +2 more
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ReumatismoBackground: BAG3 (Bcl2-associated athanogene 3) regulates apoptosis and autophagy while inducing fibroblast-to-myofibroblast transformation. In systemic sclerosis (SSc), myofibroblasts drive skin and organ fibrosis, with interstitial lung disease (ILD ...
Società Italiana di Reumatologia
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A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy
Journal of Tissue EngineeringPathogenic mutations in Bcl2-associated athanogene 3 (BAG3) cause genetic dilated cardiomyopathy (DCM), a disease characterized by ventricular dilation, systolic dysfunction, and fibrosis.
Margaretha A. J. Morsink +9 more
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Frontiers in OncologyPrevious studies identified BAG3 as a stress-induced protein with pro-survival functions in various tumors. Based on this assumption, we analyzed the expression and secretion of BAG3 in 24 cancer cell lines representing ten types of cancer and compared ...
Paola Manzo +18 more
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npj Cardiovascular HealthTo investigate the circulating BAG3 role as a biomarker across Universal Definition of Heart Failure (UDHF) stages, plasma samples from 1121 individuals undergoing coronary and/or peripheral angiography across UDHF stages were analyzed using a novel BAG3
Margot De Marco +10 more
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The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions
FEBS Open BioBcl‐2‐associated athanogene 3 (BAG3) is the only member of the BAG cochaperone family that is induced by stressful stimuli such as heat shock and heavy metals. In the present study, bag3 knockout (KO) HeLa cells were generated via the CRISPR‐Cas9 system,
Ngoc Nguyen Thi Minh +2 more
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