Stem Cell ResearchBag3 is important for protein homeostasis in mechanically stressed muscle proteins as member of the chaperone-assisted selective autophagy (CASA) complex.
Kerstin Filippi +5 more
doaj +2 more sources
The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior [PDF]
Glia, Volume 74, Issue 10, October 2026.Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith +6 more
wiley +2 more sources
Mechanism of N6-methyladenosine (m6A)-mediated upregulation of LINC00958 in the growth of cervical cancer [PDF]
Frontiers in OncologyObjectiveCervical cancer (CC) remains a prominent contributor to cancer mortality amongst women. Long non-coding RNAs (LncRNAs) participate in CC progression.
Yuting Li, Zhengying Liu, Hongling Jin
doaj +2 more sources
Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6 [PDF]
Nature CommunicationsMyofibrillar myopathy 6 is a rare, autosomal-dominant neuromuscular disorder caused by an amino acid exchange Pro209Leu in the co-chaperone BAG3, which disrupts muscle protein turnover and causes severe muscle weakness and shortened lifespan.
Kerstin Filippi +18 more
doaj +2 more sources
BAG3 regulates bone marrow mesenchymal stem cell proliferation by targeting INTS7 [PDF]
PeerJ, 2023 Background BAG3 is an essential regulator of cell survival and has been investigated in the context of heart disease and cancer. Our previous study used immunoprecipitation-liquid chromatography-tandem mass spectrometry to show that BAG3 might directly ...
Yubo Liu +4 more
doaj +2 more sources
Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity [PDF]
Nature CommunicationsNucleotide-binding leucine-rich repeat receptors (NLRs) function as core components of innate immunity in both plants and animals. In animals, NLR activation initiates caspase-mediated immune signaling.
Lin Liang +9 more
doaj +2 more sources
FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer [PDF]
Cell Communication and SignalingBackground Breast cancer (BC) is a widespread and heterogeneous disease in which autophagy plays an essential role in tumor development and progression.
Margherita Piccolella +22 more
doaj +2 more sources
The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome. [PDF]
PLoS ONE, 2009 Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such
Victoria M Virador +5 more
doaj +1 more source
Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations [PDF]
, 2018 BACKGROUND: The BAG3 (BLC2-associated athanogene 3) gene codes for an antiapoptotic protein located on the sarcomere Z-disc. Mutations in BAG3 are associated with dilated cardiomyopathy (DCM), but only a small number of cases have been reported to date ...
Franaszczyk, M +32 more
core +6 more sources
Cells, 2021 The cochaperone BCL2-associated athanogene 3 (BAG3), in complex with the heat shock protein HSPB8, facilitates mitotic rounding, spindle orientation, and proper abscission of daughter cells. BAG3 and HSPB8 mitotic functions implicate the sequestosome p62/
Carole Luthold +7 more
doaj +1 more source