Results 41 to 50 of about 7,354 (190)

Overexpression of BAG3 Attenuates Hypoxia-Induced Cardiomyocyte Apoptosis by Inducing Autophagy

Cellular Physiology and Biochemistry, 2016
Background: Hypoxia is a well-known factor in the promotion of apoptosis, which contributes to the development of numerous cardiac diseases, such as heart failure and myocardial infarction.
Jiankai Zhang, Zhangyou He, Wenjian Xiao, Qingqing Na, Tianxiu Wu, Kaixin Su, Xiaojun Cui   +6 more
doaj   +1 more source

BAG3 extracellulare: target cellulari e molecolari [PDF]

, 2016
2014 - 2015Bcl-2-associated athanogene 3 (BAG3) belongs to the family of co-chaperone proteins that interact with the heat shock protein 70 (Hsp70) and is involved in a number of cellular processes including proliferation and apoptosis. BAG3 contains the
D'Auria, Raffaella
core   +1 more source

Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth

Cell Death Discovery, 2022
The BAG3- and SIRPα- mediated pathways trigger distinct cellular targets and signaling mechanisms in pancreatic cancer microenvironment. To explore their functional connection, we investigated the effects of their combined blockade on cancer growth in ...
Margot De Marco, Vanessa Gauttier, Sabrina Pengam, Caroline Mary, Bianca Ranieri, Anna Basile, Michela Festa, Antonia Falco, Francesca Reppucci, Anna Lisa Cammarota, Fausto Acernese, Vincenzo De Laurenzi, Gianluca Sala, Sergio Brongo, Masayuki Miyasaka, Shabnam Shalapour, Bernard Vanhove, Nicolas Poirier, Roberta Iaccarino, Michael Karin, Maria Caterina Turco, Alessandra Rosati, Liberato Marzullo   +22 more
doaj   +1 more source

Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

JACC: Basic to Translational Science, 2023
Summary: B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers.
JuFang Wang, MD, Dhadendra Tomar, PhD, Thomas G. Martin, PhD, Shubham Dubey, PhD, Praveen K. Dubey, PhD, Jianliang Song, MD, PhD, Gavin Landesberg, BS, Michael G. McCormick, MS, Valerie D. Myers, PhD, Salim Merali, PhD, Carmen Merali, BS, Bonnie Lemster, MPH, Charles F. McTiernan, PhD, Kamel Khalili, PhD, Muniswamy Madesh, PhD, Joseph Y. Cheung, MD, PhD, Jonathan A. Kirk, PhD, Arthur M. Feldman, MD, PhD   +17 more
doaj   +1 more source

The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer's disease stages.

Neurobiology of Disease
Alzheimer's disease (AD) includes amyloid-β plaques and tau tangles as associated proteinopathies. Tau aggregates appear in a sequential and predictable manner, defined by six stages (Braak stages I-VI) of neuropathological diagnosis, with the ...
Carmen Soriano-Herrador, I. Úbeda-Banon, Patricia Villanueva-Anguita, D. Saiz-Sánchez, Veronica Astillero-Lopez, A. Martínez-Marcos, A. Flores-Cuadrado   +6 more
semanticscholar   +1 more source

BAG3 Suppresses Loading of Ago2 to IL6 mRNA in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2019
Pancreatic stellate cells (PSCs) are a subset of pancreatic cancer-associated fibroblasts, which play a critical role in pancreatic fibrosis, a characteristic feature of pancreatic cancer.
Chao Li, Chao Li, Ming-Xin An, Jing-Yi Jiang, Han-Bing Yao, Si Li, Jing Yan, Xin-Yu Li, Hua-Qin Wang, Hua-Qin Wang   +9 more
doaj   +1 more source

Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

Nature Communications, 2021
Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcomere ...
Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk   +8 more
doaj   +1 more source

METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3

npj Precision Oncology
Protein methyltransferases regulate diverse physiological and pathological processes through histone and non-histone substrate methylation. While the role of histone methyltransferases in tumorigenesis is well-established, the contribution of non-histone
Pin-Xin Zhan, Yizhe Cheng, Ying Wu, Jing Lu, Jing Wen, Xiaoqin Chi, Changhong Luo, Yiwei Peng, Xi-Jun Chen, Fuqiang Wang, Zhen-Yu Yin, Chengrong Xie   +11 more
semanticscholar   +1 more source

BAG3 binds αB-crystallin directly through BAG3 intermediate region.

, 2013
(A) BAG3 interacts with αB-crystallin in rat cardiomyocytes. Cardiomyocytes were isolated from rat hearts, and Flag-tagged BAG3 was expressed using adenovirus.
Shinichi Takayama (354627), Akinori Hishiya (354624), Serena Carra (354626), Harm H. Kampinga (82770), Mortada Najem Salman (354625)   +4 more
core   +1 more source

Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients

Stem Cell Research, 2023
Dilated cardiomyopathies (DCM) are one of the main causes of heart failure as one ages. BAG3 is a chaperone protein that is heavily implicated in the development of DCM and speed of progression toward heart failure.
Peter-James H. Zushin, Yang Zhou, Audrey Li, Euan A. Ashley, Matthew T. Wheeler, Joseph C. Wu   +5 more
doaj   +1 more source