Results 61 to 70 of about 7,354 (190)

Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag. [PDF]

PLoS ONE, 2012
JC virus, JCV, is a human neurotropic polyomavirus whose replication in glial cells causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML).
Ilker Kudret Sariyer, Nana Merabova, Prem Kumer Patel, Tijana Knezevic, Alessandra Rosati, Maria C Turco, Kamel Khalili   +6 more
doaj   +1 more source

Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance

Molecular Metabolism, 2023
Background: Insulin, secreted from pancreatic islets of Langerhans, is of critical importance in regulating glucose homeostasis. Defective insulin secretion and/or the inability of tissues to respond to insulin results in insulin resistance and to ...
Verena Damiani, Alessia Lamolinara, Ilaria Cicalini, Maria Concetta Cufaro, Francesco Del Pizzo, Federica Di Marco, Piero Del Boccio, Beatrice Dufrusine, Michael Hahne, Rossano Lattanzio, Damiana Pieragostino, Manuela Iezzi, Massimo Federici, Maria Caterina Turco, Arianna Maiorana, Carlo Dionisi-Vici, Vincenzo De Laurenzi   +16 more
doaj   +1 more source

Sustainable plant‐leaf‐derived carbon dots with deep‐red emission enable 1‐min photodynamic therapy of tumors

FlexMat, EarlyView.
In this study, plant‐derived carbon dots (CDs) were prepared using natural plant leaves as raw materials through solvothermal method. These CDs retain the porphyrin structure from chlorophyll and can simultaneously generate I and II types of reactive oxygen species. A 660 nm laser irradiation for only 1 min can achieve efficient photodynamic anti‐tumor
Renjing Chen, Danjie Han, Zemin Wang, Xinyi Lu, Peng He, Lili Hou, Chuantong Cheng, Xueting Liu, Jinli Liu, Zhiming Wang, Zongwen Liu, Xingtao Zhou, Zichao Luo, Kebin Lin   +13 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The prosurvival protein BAG3: a new participant in vascular homeostasis [PDF]

, 2016
Bcl2-associated athanogene 3(BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors.
Damato, Antonio, Damato, A., Ambrosio, M., FALCO, ANTONIA, VECCHIONE, Carmine, DE LAURENZI, Vincenzo, Ambrosio, Mariateresa, Januzzi, James L., ROSATI, ALESSANDRA, CARRIZZO, ALBINO, TURCO, Maria Caterina, Turco, Maria C., Januzzi, J. L., CAPUNZO, Mario, Madonna, Michele, De Laurenzi, V., Madonna, M.   +16 more
core   +1 more source

An mTOR‐Tfeb‐Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging

Aging Cell
While BAG3 has been identified as a causative gene for dilated cardiomyopathy, the major pathological events in BAG3‐related cardiomyopathy that could be targeted for therapeutic benefit remain to be discovered. Here, we aim to uncover novel pathological
Yong-He Ding, Xueling Ma, Feixiang Yan, Baul Yoon, Wei Wei, Yu-Ji Zhang, Xueying Lin, Xiao-Lei Xu   +7 more
semanticscholar   +1 more source

The BAG3-HSP70-CHIP Axis Controls the Degradation of TGFBR2 in Cardiac Fibroblasts

Journal of Molecular and Cellular Cardiology
Transforming Growth Factor Beta (TGF-β) is a master regulator of cardiac fibrosis, via type II TGF-β receptor (TGFBR2) that initiates signaling after ligand binding. We previously identified the co-chaperone protein Bcl2-associated athanogene (BAG3) as a
M. Morsink, Josephine M. Watkins, Katelyn Zhu, Xiaokan Zhang, Lori J. Luo, Barry M. Fine, Bryan Z. Wang, G. Vunjak-Novakovic   +7 more
semanticscholar   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Structural requirements on BAG3 for restoration of normal spindle dynamics in BAG3-depleted cells.

, 2015
(A) Schematic of BAG3-GFP proteins bearing mutations or deletions of functional domains and a glycine/serine-rich flexible linker peptide (GSGS) that distances the GFP moiety from the rest of the BAG3, as reported in [75]; WT, wild type.
Alice Anaïs Varlet (817680), Solenn M. Guilbert (817679), Herman Lambert (817681), Margit Fuchs (817677), Alexandra Jetté (817682), Josée N. Lavoie (817684), Carole Luthold (817678), Jacques Landry (817683), Sabine Elowe (178545)   +8 more
core   +1 more source

Identification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways.

European journal of medicinal chemistry
In the complex network of cellular physiology, the maintenance of cellular proteostasis emerges as a critical factor for cell survival, particularly under stress conditions.
Dafne Ruggiero, Emis Ingenito, Eleonora Boccia, Vincenzo Vestuto, G. D'Urso, Alessandra Capuano, A. Casapullo, S. Terracciano, Giuseppe Bifulco, G. Lauro, I. Bruno   +10 more
semanticscholar   +1 more source