Results 81 to 90 of about 7,354 (190)

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour, Shiva Esmaeili, Aydin Feyzi, Ali Sharafi, Majid Maleki, Samira Kalayinia   +5 more
wiley   +1 more source

An emerging role for BAG3 in gynaecological malignancies

, 2021
BAG3, a member of the BAG family of co-chaperones, is a multidomain protein with a role in several cellular processes, including the control of apoptosis, autophagy and cytoskeletal dynamics.
Genovese, Giovanni, Falco, Antonia, Marzullo, Liberato, Capunzo, Mario, Guida, Maurizio, Chetta, Massimiliano, Iaccarino, Roberta, Uversky, Vladimir N., Turco, Maria Caterina, De Marco, Margot, De Caro, Francesco, Rosati, Alessandra, Raffone, Antonio, Mollo, Antonio   +13 more
core   +2 more sources

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Md Mohiuddin
wiley   +1 more source

BAG3 interacts with eVP40 in a PPxY-dependent manner.

, 2017
A) Extracts from HEK293T cells transfected with eVP40 or eVP40-ΔPT/PY plus BAG3-WT were first immunoprecipitated (IP) with either normal rabbit IgG or polyclonal anti-eVP40 antisera as indicated. BAG3 was detected in the precipitates by Western blot (WB)
Jingjing Liang (413293), Ronald N. Harty (819814), Mark T. Bedford (182601), Sachdev S. Sidhu (141559), Marius Sudol (590085), Ziying Han (347945), Cari A. Sagum (3631066)   +6 more
core   +1 more source

Altered BAG3-insulin colocalization is associated with impaired first phase insulin secretion in humans.

Diabetes Research and Clinical Practice
AIMS Alterations in first-phase insulin secretion are pivotal in the early development of T2DM. BAG3 has been implicated in regulating insulin secretion in murine models, but its role in humans remains unexplored.
Verena Damiani, G. Di Giuseppe, G. Gliozzo, G. Ciccarelli, Erika Pizzinato, F. D. Del Pizzo, D. Fruci, Michela Brunetti, L. Soldovieri, G. Quero, Andrea Mari, Sergio Alfieri, A. Pontecorvi, A. Giaccari, V. De Laurenzi, T. Mezza   +15 more
semanticscholar   +1 more source

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

Protein Science, Volume 35, Issue 10, October 2026.
Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes, Maria K. Janowska, Lisa M. Tuttle, Miklos Guttman, Abhinav Nath, Rachel E. Klevit   +5 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

TTN and BAG3 in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer

JAMA Network Open
Key Points Question What is the association of TTN and BAG3 with late-onset cancer therapy–related cardiomyopathy (CCM) among childhood cancer survivors?
Achal Neupane, Kateryna Petrykey, Kendrick Li, Jennifer French, Xin Zhou, Jian Wang, C. Im, S. Dixon, M. Ehrhardt, D. Mulrooney, John L. Jefferies, M. Gramatges, Eric J. Chow, S. Bhatia, L. Robison, Kirsten K. Ness, Melissa M. Hudson, Paul W. Burridge, G. Armstrong, Yutaka Yasui, Y. Sapkota   +20 more
semanticscholar   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Expression of the Anti-Apoptotic Protein BAG3 in Human Melanomas.

, 2012
The identification of molecules that are involved in maintaining melanoma cell survival is required for a better understanding of melanoma biology (Smalley, 2010) and identification of potential markers for prediction of tumor recurrence and response to ...
Cennamo G, Franco R., Ascierto PA, Cennamo G., Ascierto P.A., SEBASTIANI, Adolfo, Sebastiani A, Franco R, Ascierto P, CENNAMO, GIOVANNI, Botti G., SALERNO, Vincenzo, ROSATI, ALESSANDRA, Turco M.C., FRANCO, Renato, Turco MC, Salerno V, TURCO, Maria Caterina, Scognamiglio G., Scognamiglio G, Botti G, Rosati A.   +21 more
core   +1 more source