Results 171 to 180 of about 7,354 (190)
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INTERACTION OF SMALL HEAT SHOCK PROTEINS WITH BAG3.
BiochimieBAG3 is a universal adapter protein involved in various cellular processes, including the regulation of apoptosis, chaperone-assisted selective autophagy, and heat shock protein function.
M. A. Zamotina +3 more
semanticscholar +1 more source
BAG3 Positivity as Prognostic Marker in Head and Neck Squamous Cell Carcinoma
CancersSimple Summary Head and neck cancers exhibit considerable heterogeneity, complicating the prediction of disease progression and treatment response. Researchers are actively investigating reliable biomarkers to forecast disease trajectories and inform ...
Pietro de Luca +17 more
semanticscholar +1 more source
Circulation
Introduction: BAG3 pathogenic variants and Charcot-Marie-Tooth (CMT) have been linked with various cardiac conditions, but rarely hypertrophic cardiomyopathy (HCM).
Jack A. Simmons +7 more
semanticscholar +1 more source
Introduction: BAG3 pathogenic variants and Charcot-Marie-Tooth (CMT) have been linked with various cardiac conditions, but rarely hypertrophic cardiomyopathy (HCM).
Jack A. Simmons +7 more
semanticscholar +1 more source
Diabetes
Introduction and Objective: Alterations in first-phase insulin secretion are pivotal in the early development of type 2 diabetes mellitus (T2DM). The multifunctional protein BAG3 has been implicated in regulating insulin secretion in murine models, but ...
G. Ciccarelli +9 more
semanticscholar +1 more source
Introduction and Objective: Alterations in first-phase insulin secretion are pivotal in the early development of type 2 diabetes mellitus (T2DM). The multifunctional protein BAG3 has been implicated in regulating insulin secretion in murine models, but ...
G. Ciccarelli +9 more
semanticscholar +1 more source
Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer‐Related Pathways
ChemMedChemContinuing the research aimed at discovering new BAG3 modulators as attractive anticancer drug candidates, a screening campaign on an in‐house library is performed, including compounds featuring a large variety of scaffolds. The obtained results prompted
Dafne Ruggiero +10 more
semanticscholar +1 more source
Biochemical Pharmacology
Over the past four decades, efforts to improve the prognosis of pancreatic cancer have yielded limited progress, largely due to the complex genetic mutations, a desmoplastic tumor microenvironment, and the rapid metabolic rewiring that enables pancreatic
Sijia Weng +6 more
semanticscholar +1 more source
Over the past four decades, efforts to improve the prognosis of pancreatic cancer have yielded limited progress, largely due to the complex genetic mutations, a desmoplastic tumor microenvironment, and the rapid metabolic rewiring that enables pancreatic
Sijia Weng +6 more
semanticscholar +1 more source
Neuropeptides
BACKGROUND Microglial NLRP3 inflammasome activation plays a central role in the neuroinflammatory cascade that contributes to the pathogenesis of various neurodegenerative diseases.
Ö. Kalkan +7 more
semanticscholar +1 more source
BACKGROUND Microglial NLRP3 inflammasome activation plays a central role in the neuroinflammatory cascade that contributes to the pathogenesis of various neurodegenerative diseases.
Ö. Kalkan +7 more
semanticscholar +1 more source
Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression.
Cancer LettersDeubiquitylases (DUBs) have emerged as promising targets for cancer therapy due to their role in stabilizing substrate proteins within the ubiquitin machinery.
Jia-Zhou Liu +11 more
semanticscholar +1 more source
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy.
American Journal of Physiology. Heart and Circulatory PhysiologyThe co-chaperone BAG3 is a central node in protein quality control in the heart. In humans and animal models, decreased BAG3 expression is associated with cardiac dysfunction and dilated cardiomyopathy.
Thomas G Martin +2 more
semanticscholar +1 more source