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Baicalin Blocks Colon Cancer Cell Cycle and Inhibits Cell Proliferation through miR-139-3p Upregulation by Targeting CDK16.

The American Journal of Chinese Medicine, 2023
Baicalin was reported to facilitate the apoptosis of colon cells and inhibit tumor growth in vivo. This study aimed to explore the specific mechanism and function of baicalin on colon cells. Relative mRNA levels were tested via qPCR.
R. Cai   +4 more
semanticscholar   +1 more source

Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease

Frontiers in Pharmacology
Baicalin is a flavonoid glycoside obtained from the dried root of Scutellaria baicalensis Georgi, which belongs to the Labiatae family. Accumulating evidence indicates that baicalin has favorable therapeutic effects on cardiovascular diseases.
Lujia Si, Yu Lai
semanticscholar   +1 more source

Simple preparation of baicalin from Scutellariae Radix

Journal of Chromatography A, 2009
A simple, rapid and reproducible method was developed to isolate high-purity baicalin from Scutellariae Radix, the dried roots of Scutellaria baicalensis Georgi. The method involves partition/recrystallization steps without repeated column chromatography or special instruments.
Emika, Ohkoshi   +5 more
openaire   +2 more sources

Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin

Archives of Pharmacal Research, 2014
Baicalin is a flavonoid compound purified from the medicinal plant Scutellaria baicalensis Georgi and has been reported to possess anti-inflammatory and anti-viral activities. However, antiplatelet, anticoagulant, and profibrinolytic properties of baicalin have not been studied.
Wonhwa, Lee   +2 more
openaire   +2 more sources

Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens

Journal of Animal Science and Biotechnology
Background Baicalin and probiotic cocktails are promising feed additives with broad application prospects. While probiotic cocktails are known to enhance intestinal health, the potential synergistic impact of combining baicalin with probiotic cocktails ...
Mingkun Gao   +5 more
semanticscholar   +1 more source

Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review

European Journal of Drug Metabolism and Pharmacokinetics, 2018
Baicalin is one of the major bioactive components of Scutellaria radix, a Chinese herb that has been used since ancient times. Baicalin has various pharmacological activities, including antitumor, antimicrobial, and antioxidant, and has wide clinical applications.
Cheng-Liang Zhang
exaly   +3 more sources

Anticancer Properties of Baicalin against Breast Cancer and other Gynecological Cancers: Therapeutic Opportunities based on Underlying Mechanisms.

Current Molecular Pharmacology
Gynecological cancers are serious life-threatening diseases responsible for high morbidity and mortality around the world. Chemotherapy, radiotherapy, and surgery are considered standard therapeutic modalities for these cancers.
M. H. Pourhanifeh   +4 more
semanticscholar   +1 more source

Baicalein and baicalin as Zika virus inhibitors

Archives of Virology, 2018
At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells.
Oo, Adrian   +4 more
openaire   +3 more sources

Anti-ROS and NIR-II-responsive Hyaluronic Acid Microneedle Loaded with Baicalin Nanoparticles for Treatment of Psoriasis.

Macromolecular rapid communications
In the work, we designed a natural medicine baicalin for the treatment of psoriasis with the aid of hyaluronic acid (HA)-based MNs patches. In order to improve the solubility of baicalin and increase its residence time in infected part, which was made ...
Chuanlan Xia   +6 more
semanticscholar   +1 more source

Microbial transformation of baicalin and baicalein

Journal of Molecular Catalysis B: Enzymatic, 2007
Abstract As a result of microbial transformation of baicalin and baicalein the products of 4 -hydroxylation of the B ring, O -methylation at C-6, and both O -methylation at C-6 and hydroxylation at C-4 were obtained. Transformations of baicalin were accompanied by the reaction of hydrolysis.© 2007 Elsevier B.V. All rights reserved.
Edyta Kostrzewa-Susłow   +2 more
openaire   +1 more source

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