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When Research Serves Good Purposes
Voices in Bioethics, 2021 Photo by Scott Graham on Unsplash INTRODUCTION It is a classic ethical dilemma to have something of potential value that comes at a tremendous cost to others.[1] To access the good, you must have the bad.
Kenneth Kirkwood
doaj
A Conceptual and Foundational Analysis of the 'Deemed Contract' in Islamic Law and the Iranian Legal System [PDF]
پژوهشنامه حقوق اسلامی∴ Introduction ∴ The concept of a “deemed contract” has emerged from instances where the legislator, departing from the conventional requirement of mutual consent, imposes the effects of a contractual relationship upon parties that may never have ...
Seyyed Mostafa Saadat Mostafavi +1 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Establishing Confidence in Safety Assessment Evidence [PDF]
, 2012 With the increased complexity and higher safety commitment of modern safety–critical systems, safety assessment models of these systems are increasingly complicated and obscure.
Sun, Linling
core
ZaakenOne of the factors that husband and wife often dispute is regarding propertya especially joint property. Generally, disputes regarding joint property arise after a couple decides to divorce.
Salma Wati, Zulfan Zulfan, Elfia Elfia
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
An Interview with Tom Beauchamp, Early Bioethics Innovator
Voices in Bioethics, 2016 Tom Beauchamp, PhD, has been a principle pioneer in the field of bioethics. As a young philosophy professor at Georgetown, he created the first applied ethics program in the United States. In 1975, he was recruited by the newly formed National Commission
Elizabeth Galt
doaj +1 more source