Results 41 to 50 of about 292,971 (242)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Using artificial intelligence in academic writing and research: An essential productivity tool
Computer Methods and Programs in Biomedicine UpdateBackground: Academic writing is an essential component of research, characterized by structured expression of ideas, data-driven arguments, and logical reasoning. However, it poses challenges such as handling vast amounts of information and complex ideas.
Mohamed Khalifa, Mona Albadawy
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Evolutionary Debunking Arguments in Ethics
, 2014 I consider whether evolutionary explanations can debunk our moral beliefs. Most contemporary discussion in this area is centred on the question of whether debunking implications follow from our ability to explain elements of human morality in terms of ...
Mogensen, Andreas Lech +2 more
core +2 more sources
Bulletin of the World Health Organization, 2001 The syndromic treatment of gonococcal and chlamydial infections in women seeking primary care in clinics where resources are scarce, as recommended by WHO and implemented in many developing countries, necessitates a balance to be struck between ...
Behets Frieda M-T.F. +2 more
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2023 This article will focus upon the law on negligently caused psychiatric harm. It will investigate whether the current law strikes a fair balance between compensating those who suffer psychiatric harm as a result of another’s negligence, keeping in line ...
Manning-Crisp, Freya
core
Three Cambridge Arguments for Experientialism [PDF]
, 2023 Call Experientialism the view that experience is constitutive of mentality. This view was once prominent in the Cambridge School of analysis. Drawing on considerations offered by Cambridge philosophers, this chapter features three independent arguments ...
Dewalque, Arnaud
core