Results 111 to 120 of about 592,802 (306)
Tipping the balance: the problematic nature of work–life balance in a low-income neighbourhood.
The article attempts to locate the contested notion of work–life balance within the context of global trends and recent policy developments. It describes a small-scale qualitative study of work–life balance as it is experienced within a low-income ...
Dean, Hartley
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Balance of Intergenerational Interests and the Improvement of Social Security System
, 2012 本文认为分析代际利益均衡对于社会和谐具有重大意义,指出代际利益均衡是和谐社会的必然要求。代际利益均衡不能通过市场机制自发实现,只能通过社会保障制度来实现,因而代际利益均衡机制建设是社会保障制度建设的重要任务。最后分析了青少年、中青年及老年人三个代际间的利益均衡机制,从而推进社会保障制度的完善。The paper argues that the balance of intergenerational interests is significant for social harmony and ...
庄三红, 徐国冲
core
Safety of participants of criminal trial and ensuring balance of interests of charge and protection
, 2018 Ensuring the safety of participants in criminal proceedings is one of the important guarantees for the achievement of the goal of modern Russian criminal justice: involvement of a guilty person or release of an innocent person from punishment.
Epikhin, Alexander Yu.
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Ensuring Military-Political Security in USSR and FRG Dialogue (1987–1989)
Научный диалогThis article is dedicated to the examination of the diplomatic efforts undertaken by the USSR and the Federal Republic of Germany (FRG) to ensure military-political security during the period from 1987 to 1989. It explores the factors that contributed to
A. I. Egorov
doaj +1 more source
Balancing interests, needs, and resources
Eos, Transactions American Geophysical Union, 1996 To conduct activities beyond publications and meetings, the Union depends increasingly on your contributions. For many years, the publications and meetings programs provided sufficient surplus to fund public affairs, public information, and education programs; to provide travel grants to students; and to extend the helping hand of the Union to ...
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Problemy Ekorozwoju, 2017 The article proposes a new perspective on the issues of development of the system of specially protected natural areas (SPNAs) in the context of the concept of sustainable development.
Aleksey Anisimov +2 more
doaj