Results 91 to 100 of about 3,216,885 (288)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

US-IRAN: Between Confrontation and Reconciliation

open access: yesInformaciâ i Innovacii
The US policy towards Iran is a part and parcel of its broader policy towards the Middle East and the Arabian (Persian) Gulf in particular. Most of the American targets, whether in the Middle East or Asia, are related to Iran, due to its possession of ...
V. I. Belov   +2 more
doaj   +1 more source

The Race towards the Future: Geopolitics versus Technology. Implications for Romania [PDF]

open access: yesRomanian Journal of European Affairs, 2017
The paper identifies two broad and unrelated processes that take place in contemporary world economy, the historical process of redefinition of the balance of power and spheres of influence which is characterized by the geopolitical dimension and the ...
Florin Bonciu
doaj  

MACROECONOMIC ADJUSTMENT AND THE BALANCE OF BARGAINING POWER IN RURAL WEST AFRICAN HOUSEHOLDS [PDF]

open access: yes
The example of cotton-producing households in Burkina Faso is used to investigate (1) how price-shifting macroeconomic adjustment policies affect the balance of bargaining power between spouses in West African households and (2) how the balance of power ...
Smith, Lisa C.
core   +1 more source

Weblog patterns and human dynamics with decreasing interest

open access: yes, 2010
Weblog is the fourth way of network exchange after Email, BBS and MSN. Most bloggers begin to write blogs with great interest, and then their interests gradually achieve a balance with the passage of time.
A. Kentsis   +21 more
core   +2 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Nuclear Dynamics at the Balance Energy

open access: yes, 2003
We study the mass dependence of various quantities (like the average and maximum density, collision rate, participant-spectator matter, temperature as well as time zones for higher density) by simulating the reactions at the energy of vanishing flow ...
A. D. Sood   +4 more
core   +1 more source

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