Results 51 to 60 of about 514,859 (264)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Westphalian System of International Relations: Formation Dynamics and Disintegration Factors
Научный диалогThis article explores the formation and evolution of the system of international relations, asserting that the principles established by the Peace of Westphalia in 1648, which marked the conclusion of the Thirty Years’ War, fundamentally transformed ...
I. A. Kunina
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Meridiano 47, 2017 This essay is focused on the presentation of the various ways of conceptualizing geopolitics in its academic and practical aspects, within the framework of the State.
João Fábio Bertonha
doaj
INTERNATIONAL LAW, AN INSTRUMENT OF POWER POLITICS? [PDF]
Annals: Series on Military Sciences, 2019 We have always viewed international law as a cultural and historic product of the European doctrines that have been extended to the rest of the world.
Lisa-Maria ACHIMESCU
doaj
The Power of Filling in Balanced Allocations
SIAM Journal on Discrete MathematicsWe introduce a new class of balanced allocation processes which are primarily characterized by "filling" underloaded bins. A prototypical example is the Packing process: At each round we only take one bin sample, if the load is below the average load, then we place as many balls until the average load is reached; otherwise, we place only one ball.
Dimitrios Los +2 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
EVALUATION OF THE INTERNATIONAL SYSTEM IN RUSSIAN OFFICIAL DISCOURSE AND ACADEMIC ANALYSIS
Vestnik MGIMO-Universiteta, 2016 The article draws a comparison between Russian official and expert foreign policy discourses, focusing on representations of the power balance and relations between major states as the defining features of international system.
I. A. Istomin
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source