Results 81 to 90 of about 6,870 (233)

Sleep Preserves, Wake Differentiates: Strength‐Dependent Forgetting of Declarative Memories Across the Retention Interval

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep benefits memory, but the extend to which this benefit depends on initial memory strength remains heavily debated. We examined whether sleep preferentially stabilises weakly versus strongly encoded declarative memories, and whether classical sleep oscillations contribute to this effect.
M. Schabus, M. S. Ameen, D. P. J. Heib
wiley   +1 more source

Strong and Weak Episodic Memories Are Shaped by Multiple Cycles of NREM Spindles and REM Alpha Bursts

Journal of Sleep Research, EarlyView.
ABSTRACT Prior research has built up the notion that non‐rapid eye movement sleep (NREM) and rapid eye movement sleep (REM) are separately important for specific types of memory. However, growing evidence suggests that these sleep stages work in conjunction to jointly shape memory.
A. E. Shuster, E. A. McDevitt, S. C. Mednick   +2 more
wiley   +1 more source

Motor Sequence Learning Under Sleep Deprivation

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep deprivation (SD) compromises declarative memory encoding and subsequent consolidation, yet its consequences for the acquisition of new motor skill learning remain unknown. Forty‐eight healthy adults underwent either one night of total SD or normal sleep and were tested the next morning using a multimodal approach combining psychomotor ...
Guillaume Digonet, Thomas Lapole, Juliette Gélébart, Jérémie Bouvier, Mélanie Prudent, Vincent Pialoux, Maxime Pingon, Emeric Stauffer, Ursula Debarnot   +8 more
wiley   +1 more source

Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction [PDF]

Pharmacol Res Perspect
ABSTRACT Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic strategy for cancer. Metformin, a widely used biguanide antidiabetic drug, has recently been reported to induce ferroptosis and exert anticancer effects in various malignancies.
Jang S, Kim S, Kim G, Hong J, Park I, Jin H.   +5 more
europepmc   +2 more sources

The Accuracy Smoothness Dilemma in Prediction: A Novel Multivariate M‐SSA Forecast Approach

Journal of Time Series Analysis, EarlyView.
ABSTRACT Forecasting presents a complex estimation challenge, as it involves balancing multiple, often conflicting, priorities and objectives. Conventional forecast optimization methods typically emphasize a single metric, such as minimizing the mean squared error (MSE), which may neglect other crucial aspects of predictive performance. To address this
Marc Wildi
wiley   +1 more source

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P‐Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley   +1 more source

Insula–cerebellar functional connectivity associated with somatic symptoms in mood disorders: Differential patterns and longitudinal evidence in major depressive disorder

Psychiatry and Clinical Neurosciences, EarlyView.
Aim This study aimed to identify the resting‐state functional connectivity (rsFC) of insula subregions associated with nonspecific somatic symptoms in mood disorders and to examine whether these connections are state‐dependent. Methods In Phase 1, seed‐based rsFC analyses were performed using 12 insula subregions from the Brainnetome Atlas in patients ...
Shin Hattori, Toshiharu Kamishikiryo, Alan S. R. Fermin, Yoichiro Matsumoto, Yuki Mitsuyama, Eri Itai, Yoshikazu Masuda, Go Okada   +7 more
wiley   +1 more source

Passive thigh heating improves peak force production in younger adults and early isokinetic force production in younger and older adults

Experimental Physiology, EarlyView.
Abstract Older adults often suffer from reduced physical capability relative to young adults, in part due to impaired muscle function. This study investigated the ergogenic effects of passive thigh heating on knee extensor torque production in healthy older versus younger adults.
Desmond Denny, Daniel C. Low, Oliver R. Gibson   +2 more
wiley   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source