Results 51 to 60 of about 86,443 (297)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A Note on a Family of Resolvable Balanced Incomplete Block Designs [PDF]

open access: yes, 1970
6 pages, 1 article*A Note on a Family of Resolvable Balanced Incomplete Block Designs* (Hedayat, A.; Raktoe, B.
Cornell University. Biometrics Unit.   +4 more
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

New Combinatorial Construction Techniques for Low-Density Parity-Check Codes and Systematic Repeat-Accumulate Codes [PDF]

open access: yes, 2012
This paper presents several new construction techniques for low-density parity-check (LDPC) and systematic repeat-accumulate (RA) codes. Based on specific classes of combinatorial designs, the improved code design focuses on high-rate structured codes ...
Gruner, Alexander, Huber, Michael
core   +1 more source

Nested balanced incomplete block designs

open access: yesDiscrete Mathematics, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Morgan, J. P.   +2 more
openaire   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Two-level Cretan matrices constructed using SBIBD

open access: yesSpecial Matrices, 2015
Two-level Cretan matrices are orthogonal matrices with two elements, x and y. At least one element per row and column is 1 and the other element has modulus ≤ 1.
Balonin N. A., Seberry Jennifer
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein   +7 more
wiley   +1 more source

On imputation for planned missing data in context questionnaires using plausible values: a comparison of three designs

open access: yesLarge-scale Assessments in Education, 2018
Background This paper extends a recent study by Kaplan and Su (J Educ Behav Stat 41: 51–80, 2016) examining the problem of matrix sampling of context questionnaire scales with respect to the generation of plausible values of cognitive outcomes in large ...
David Kaplan, Dan Su
doaj   +1 more source

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