Results 121 to 130 of about 1,737,261 (319)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

LM-CLIP: Adapting Positive Asymmetric Loss for Long-Tailed Multi-Label Classification

IEEE Access
Accurate multi-label image classification is essential for real-world applications, especially in scenarios with long-tailed class distributions, where some classes appear frequently while others are rare. This imbalance often leads to biased models that
Christoph Timmermann, Seunghyeon Jung, Miso Kim, Woojin Lee   +3 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Improving long‐tail classification via decoupling and regularisation

CAAI Transactions on Intelligence Technology
Real‐world data always exhibit an imbalanced and long‐tailed distribution, which leads to poor performance for neural network‐based classification. Existing methods mainly tackle this problem by reweighting the loss function or rebalancing the classifier.
Shuzheng Gao, Chaozheng Wang, Cuiyun Gao, Wenjian Luo, Peiyi Han, Qing Liao, Guandong Xu   +6 more
doaj   +1 more source

Cluster Computing and the Power of Edge Recognition

, 2005
We study the robustness--the invariance under definition changes--of the cluster class CL#P [HHKW05]. This class contains each #P function that is computed by a balanced Turing machine whose accepting paths always form a cluster with respect to some ...
Hemaspaandra, Lane A., Homan, Christopher M., Kosub, Sven   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Bayesian state estimation for partially observable distribution networks via power flow-informed neural networks

International Journal of Electrical Power & Energy Systems
The performance of existing distribution network state estimation (SE) methods is unsatisfactory due to limited real-time measurements. In this paper, a Bayesian SE method is proposed for partially observable distribution networks using a novel power ...
Dong Liang, Guirong Li, Xiaoyu Liu, Lin Zeng, Hsiao-Dong Chiang, Shouxiang Wang   +5 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source